Studies on Function and its Disorder of the Frontal Association Cortex

额叶联合皮层功能及其紊乱的研究

基本信息

批准号：
62440024
负责人：
SASAKI Kazuo
金额：
$ 14.27万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (A)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1990
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62440024/
关键词：
frontal association cortex cortical field potential visually initiated movement color discrimination task event-related potential monkey human 大脳皮質フィールド電位視覚始動性運動

项目摘要

We investigated function of the frontal association cortex and its disorder in monkeys, and then in humans on the basis of data obtained by monkey experiments. The results will be summarized in two main topics as follows.1. The frontal association cortex for decision (judgment) and suppressor action A monkey was tasked with go/no-go reaction-time hand movement with discrimination between two different color light stimuli. Visual stimulus of a color was accompanied by reward when the monkey lifted a lever by its hand within 500 ms duration of the stimulus, whereas that of another color was not. When the monkey gradually ceased in responding to the latter (no-go) stimulus, a potential appeared and developed in the prefrontal cortex of both hemispheres, specifically to the no-go stimulus, called 'no-go potential'. The potential is composed of surface-negative, depth-positive (s-N, d-P) deflections at a latency of 85-150 ms and localized in the dorsal bank of the principal sulcus and the r … More ostroventral corner of the prefrontal cortex. Modes of appearance and development of the potential suggest that the activity of the cortical loci is related to decision or judgment not to move and to subsequent suppression of the go reaction. The suppressor action was substantiated by stimulation experiment of the cortical loci.2. The frontal association cortex for expectancy of coming stimulus and mental concentration We gave warning-imperative stimuli with a fixed time interval (e. g. ls) to a monkey so that it could lift a lever immediately after the onset of imperative stimulus. In fact, the monkey, after enough trained, moved at very short latencies. Following initial visual evoked potentials on the warning stimulus, s-N, d-P sustained slow potentials toward the imperative stimulus were recorded in wide areas of the prefrontal and premotor cortices in both hemispheres. The short latency movement was scarcely in fluenced by cerebellar hemispherectomy ipsilateral to the moving hand, which was quite different from the case of simple reaction-time hand movement. This may imply that the sustained activity of the frontal association cortex on the warning-imperative stimulus can overcome cerebellar deficiency to some extent.3. Studies in human subjects No-go potential was recorded also from the human scalp on the same go/no-go task. It spreads over the frontal part of scalp widely with the maximum at the vertex (Fz). The warning-imperative stimulus induces contingent negative variation (CNV) on the human scalp. Sustained activities of the frontal association cortex must be related to mental concentration on the coming stimulus. Less

我们根据猴子实验获得的数据研究了额叶缔合皮质及其障碍的功能，然后研究了人类的功能。结果将在两个主要主题中总结如下1。决策（判断）和抑制作用动作的额叶关联皮层猴子的任务是go/no-go反应时间移动，并在两个不同的颜色光刺激之间进行歧视。当猴子在刺激的500毫秒内通过手举起杠杆将杠杆抬起，而另一种颜色则没有。当猴子在响应后来的刺激方面逐渐停止时，在两个半球的前额叶皮层中出现并发育了潜力，特别是对无刺激的刺激，称为“无go潜力”。电势由表面阴性，深度阳性（S-N，D-P）偏转的潜伏期为85-150毫秒，并位于主要硫磺的背库和R…前额叶皮质的骨另一个角落。外观和潜力的发展模式表明，皮质区域的活性与决策或判断不移动和随后抑制GO反应有关。抑制剂作用通过皮质位置的刺激实验证实。2。额叶关联对即将到来的刺激和精神浓度的期望的皮层，我们给猴子提供了警告刺激性的刺激（例如LS），以便在当务之急刺激发作后立即抬起杠杆。实际上，经过足够的训练，猴子以非常短的延迟感动。在警告刺激上最初的视觉引起的电势之后，在两个半球的前额叶和前骨皮层的广泛区域都记录了S-N，D-P持续的对命令性刺激的缓慢潜力。短等潜伏期的运动几乎没有被小脑半球切除术同侧与移动手相关的流动，这与简单的反应时间移动的情况截然不同。这可能表明，额叶关联皮层对警告性刺激的持续活性可以在某种程度上克服小脑缺乏。3。在人类头皮上，对人类受试者的研究也记录在同一任务中。它散布在头皮的额叶上，最大值在顶点（Fz）。警告刺激性刺激会引起人头皮上的偶然性变异（CNV）。额叶协会皮层的持续活动必须与即将到来的刺激的精神集中有关。较少的