Onset mechanism of psychiatric disorders related to the biological clock abnormalities and their treatment

生物钟异常相关精神疾病的发病机制及其治疗

基本信息

批准号：
62304044
负责人：
TAKAHASHI Saburo
金额：
$ 9.02万
依托单位：
Shiga University of Medical Science
依托单位国家：
日本
项目类别：
Grant-in-Aid for Co-operative Research (A)
财政年份：
1987
资助国家：
日本
起止时间：
1987 至 1989
项目状态：
已结题

项目摘要

This research project team was organized to clarify what function of the biological clock is out of order in the diseases to which circadian rhythm abnormalities relate and what treatment would be effective for those disorders.1. Experimental research using animals. Using golden hamsters which have photoperiodism, evidence was established for their reactions to photoperiod are related to their experiences of having exposured to the light and their developmental stages. In rats changes in the living conditions had definitely alter their free-running period. Circadian rhyhtms of the pineal of the mother was transmitted to the pups by way of melatonin. Acrophase of the circadian rhythm delayed in rats kept in the dim light and shortened photoperiod, while it advanced by the treatment with photopulsations, thus these animals can be used as an animal model of the seasonal affective disorder.2. Basic research in humans. Evidence for the phase response curve to the light in humans was obtaine … More d by the experiments in which volunteers living in an isolation unit were observed their temperature rhythms longitudinally. Inter-individual difference in the melatonin secretion patterns to various light intensities was evident in the normal volunteers, and Orientals were commonly lower sensitivity to the light than Caucasians. Interval feeding in the severely ill patients unable to eat showed changes in the timing of feeding shifted the phase of their circadian rhythms of not only glucose and insulin levels but cortisol in plasma. This may suggest strong association of nutritional intake schedule with circadian rhythms. In children with severe brain damage had abnormalities of body temperature rhythm that suggests localization of the clock mechanism in the brain.3. Clinical Investigations. Multi-center collaborative survey was carried out for seasonal affective disorder in Japanese population. 46 suspected individuals were identified through investigation of population responded to mass media advertisemes. Relationship of onset of depressive episodes to the season, clinical features of this disorder were analyzed and comparison was made with previous data in other populations. Many similarities were noticed while sex ratio in Japanese population was rather low as 1:1.4 (m:f). Equipments for phototherapy were deviced and applied to these patients and proved to have efficacy. Phototherapy was found to be effective to other disorders such as senile dementias and sleep disorders. Deep body temperature rhythms were variablly disturbed in depression. Less

该研究项目团队的组织是为了阐明生物钟的功能在与昼夜节律异常相关的疾病中的秩序失效，以及哪些治疗方法对这些疾病有效。1。使用动物的实验研究。使用具有光周期性的金仓鼠，为其对光周期的反应建立了证据与他们暴露于光及其发育阶段的经验有关。在老鼠中，生活条件的变化肯定改变了自由运行时期。母亲的松果的昼夜节律通过褪黑激素传播到幼犬。昼夜节律的杂音延迟在昏暗的光线下延迟并缩短光周期，同时通过光量处理的治疗前进，因此这些动物可以用作季节性情感障碍的动物模型。2。人类的基础研究。获得了人类光的相位响应曲线的证据……通过纵向观察到居住在隔离单元中的志愿者的志愿者纵向观察到其温度节奏的实验。褪黑激素分泌模式与各种光线实例的个体间差异是正常志愿者的证据，而东方人通常比高加索人对光的敏感性低。在喂养时间的严重患者中的间隔喂养表明，喂养时间的变化改变了其昼夜节律的阶段，不仅是葡萄糖和胰岛素水平，而且还改变了血浆中的皮质醇。这可能表明，营养摄入时间表与昼夜节律有很强的联系。在严重脑损伤的儿童中，体温节奏异常，这表明大脑中时钟机制的定位。3。临床研究。对日本人口的季节性情感障碍进行了多中心协作调查。 46个可疑的人是通过对大众媒体广告做出回应的人口的调查来确定的。抑郁发作与季节的发作关系，分析了该疾病的临床特征，并与其他人群的先前数据进行了比较。人们注意到许多相似之处，而日本人口的性别比相当低至1：1.4（m：f）。光疗设备被贬低并应用于这些患者，并被证明具有有效性。发现光疗对其他疾病（例如老年痴呆症和睡眠障碍）有效。深层体温节奏在抑郁症中受到不同的干扰。较少的