Development of rapid and sensitive bioassay methods to contribute to actinide internal exposure medical response

开发快速、灵敏的生物测定方法，有助于锕系元素内照射医疗反应

• 批准号: 22K12384
• 负责人: 楊 国勝
• 金额: $ 2.66万
• 依托单位: National Institutes for Quantum Science and Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K12384/
• 关键词: Actinides; Bioassay; Radiation emergency; Dose assessment; ICP-MS/MS; Cell gas; アクチニド; バイオアッセイ; 被ばく医療; 質量分析法

Synthesized faecal sample was used for actinide analytical method development in feces, with the purpose of rapid emergency response on potential radiological/nuclear accidents. High recoveries (>80%) for Np, Pu, and Am/Cm have been obtained after ashing, borate fusion, CaF2 coprecipitation, and chromatographic purification. To increase the signal intensity of actinides in ICP-MS/MS analysis, 7.5 mL/min He has be introduced into the collision/reaction cell, along with the application of APEX-Q/ACM introduction system＋x type lens. The developed method was validated by participating in the annual intercomparison organized by PROCORAD, France.

合成的粪便样品用于粪便中的静脉分析方法开发，目的是对潜在的放射线/核事故的快速应对响应。 NP，PU和AM/CM的高回收率（> 80％）是在Ashing，Bote Fusion，CAF2复位和色谱纯化后获得的。为了增加ICP-MS/MS分析中actinides的信号强度，将7.5 ml/min的含量引入了碰撞/反应细胞中，以及Apex-Q/ACM简介系统 + X型镜头的应用。通过参加法国普罗普拉德（Procorad）组织的年度对比度来验证开发的方法。

项目成果

Rapid measurement of actinides in urine by mass and alpha spectrometric methods

通过质谱和 α 光谱方法快速测量尿液中的锕系元素

• DOI: 10.1093/rpd/ncad005
• 发表时间: 2023
• 期刊: Radiation Protection Dosimetry
• 影响因子: 1
• 作者: Gohara S;Shinohara K;Yoshida R;Kariya R;Tazawa H;Hashimoto M;Inoue J;Kubo R;Nakashima H;Arita H;Kawaguchi S;Yamana K;Nagao Y;Iwamoto A;Sakata J;Matsuoka Y;Takeshita H;Hirayama M;Kawahara K;Nagata M;Hirosue A;Kuwahara Y;Fukumoto M;Ok;Guosheng Yang; Jian Zheng; Munehiko Kowatari; Eunjoo Kim; Osamu Kurihara
• 通讯作者: Guosheng Yang; Jian Zheng; Munehiko Kowatari; Eunjoo Kim; Osamu Kurihara

Development of a new bioassay laboratory at QST

QST 开发新的生物测定实验室

• 发表时间: 2022
• 作者: Yang;G.;Tamakuma;Y.;Naito;M.;Seno;H.;Tani;K;Kim;E.;Kowatari;M.;Kurihara;O.
• 通讯作者: O.

Rapid analysis of Sr-90 in small volume of urine by ICP-MS/MS after chromatographic purification

色谱纯化后通过 ICP-MS/MS 快速分析少量尿液中的 Sr-90

• 发表时间: 2022
• 作者: Yang;G.;Kim;E.;Zheng;J.;Kowatari;M.;Kurihara;O.
• 通讯作者: O.

Rapid fecal and urinary bioassay for the measurement of multiple actinide isotopes

用于测量多种锕系同位素的快速粪便和尿液生物测定

• 发表时间: 2022
• 作者: Yang;G.;Kim;E.;Zheng;J.;Kowatari;M.;Kurihara;O.
• 通讯作者: O.

The new QST bioassay laboratory in Chiba Japan

日本千叶新的 QST 生物测定实验室

• DOI: 10.1093/rpd/ncac198
• 发表时间: 2022
• 期刊: Radiation Protection Dosimetry
• 影响因子: 1
• 作者: Gohara S;Shinohara K;Yoshida R;Kariya R;Tazawa H;Hashimoto M;Inoue J;Kubo R;Nakashima H;Arita H;Kawaguchi S;Yamana K;Nagao Y;Iwamoto A;Sakata J;Matsuoka Y;Takeshita H;Hirayama M;Kawahara K;Nagata M;Hirosue A;Kuwahara Y;Fukumoto M;Ok;Guosheng Yang; Jian Zheng; Munehiko Kowatari; Eunjoo Kim; Osamu Kurihara;Guosheng Yang; Kotaro Tani; Munehiko Kowatari; Yuki Tamakuma; Masayuki Naito; Eunjoo Kim; Osamu Kurihara
• 通讯作者: Guosheng Yang; Kotaro Tani; Munehiko Kowatari; Yuki Tamakuma; Masayuki Naito; Eunjoo Kim; Osamu Kurihara