Innate immunity and treatment response in chronic viral hepatitis

慢性病毒性肝炎的先天免疫和治疗反应

• 批准号: 25293169
• 负责人: Asahina Yasuhiro
• 金额: $ 11.81万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293169/
• 关键词: HCV; IFNλ4; IL28B; IFNλ3; 自然免疫; インターフェロン; HBV; ウイルス肝炎

项目成果

Serial changes in M2BPGi levels as predictors of fibrosis and HCC in chronic hepatitis C.

M2BPGi 水平的连续变化作为慢性丙型肝炎纤维化和 HCC 的预测因子。

• 发表时间: 2016
• 作者: Nagata H;Sakurai Y;Nakagawa M;Kakinuma S;Azuma S;Murakawa M;Nitta S;Itsui Y;Asahina Y;Watanabe M
• 通讯作者: Watanabe M

Impact of host and therapeutic factors and resistant associated variants on response to interferon based- direct acting antiviral treatment in difficult-to-treat chronic hepatitis C patients.

宿主和治疗因素以及耐药相关变异对难治性慢性丙型肝炎患者基于干扰素的直接作用抗病毒治疗的影响。

• 发表时间: 2014
• 作者: Nakagawa M;Asahina Y;Taniguchi M;Watanabe T;Nishimura-Sakurai Y;Itsui Y;Azuma S;Kakinuma S;Tanaka Y;Watanabe M.
• 通讯作者: Watanabe M.

Clinical Characteristics of Patients who Developed Hepatocellular Carcinoma after Hepatitis C Virus Eradication with Interferon Therapy: Current Status in Japan

用干扰素治疗根除丙型肝炎病毒后发展为肝细胞癌的患者的临床特征：日本现状

• DOI: 10.2169/internalmedicine.52.1180
• 发表时间: 2013
• 期刊: Internal Medicine
• 影响因子: 1.2
• 作者: Sato A;SataM;Ikeda K;Kumada T;Izumi N;Asahina Y;Osaki Y;Chayama K;Kaneko S;Sakai A;Onji M;Hiasa Y;Omura T;Ozeki I;Yokosuka O;Shiina S;Itsubo M;Nishiguchi S;Hirano K;Ide T;Sakisaka S;Yamasaki T;Hidaka I;Tanaka M;Kim SR;Ichida T.
• 通讯作者: Ichida T.

Expression of IFN lambda 4 in liver is closely associated with non-response to antiviral therapy through the regulation of basal expression of ISGs in chronic hepatitis C patients but not in hepatitis B.

肝脏中 IFN lambda 4 的表达通过调节慢性丙型肝炎患者 ISG 的基础表达与抗病毒治疗无反应密切相关，但在乙型肝炎中则不然。

• 发表时间: 2015
• 作者: Murakawa M;Asahina Y;Kawai-Kitahata F;Nagata H;Kaneko S;Nitta S;Watanabe T;Itsui Y;Nakagawa M;Kakinuma S;Iijima S;Tanaka Y;Watanabe M;Tanaka Y
• 通讯作者: Tanaka Y

Expression of IFN/.4 in liver and PBMC is closely associated with higher basal expression of ISGs and impaired induction of IL28B by interferon treatment in chronic hepatitis C non-responder patients.

肝脏和 PBMC 中 IFN/.4 的表达与 ISG 基础表达升高以及慢性丙型肝炎无反应患者干扰素治疗导致的 IL28B 诱导受损密切相关。

• 发表时间: 2014
• 作者: Murakawa M;Asahina Y;Nakagawa M;Sakamoto N;Nitta S;Kawai-Kitahata F;Taniguchi M;Watanabe T;Itsui Y;Kakinuma S;Watanabe M.
• 通讯作者: Watanabe M.