RESEARCH FOR SEROEPIDEMIOLOGY OF GBV-C/HGV INFECTION

GBV-C/HGV 感染的血清流行病学研究

• 批准号: 09670391
• 负责人: TANAKA Junko
• 金额: $ 2.11万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09670391/
• 关键词: GBV-C; HGV; Seroepidemiology; high risk group; post transfusion hepatitis; NonANonBNonC hepatitis; ハイリスク集団; 非A非B型肝炎; 慢性関節リウマチ

The prevalence of GB virus C (GBV-C) / hepatitis G virus (HGV) was studied. Serum samples obtained from various groups were tested for GBV-C/HGV RNA by reverse-transcription polymerase chain reaction.1. Among the 23 patients with post-transfusion Non-B, Non-C hepatitis, none was positive for GBV-C/FIGV RNA.Of 217 patients with normal serum aminotransferase level after transfusion, six (2.8%) were positive for GBV-C/HGV RNA.2. High positive rates of GBV-C/HGV RNA were noted among intravenous drug users (13.2%), hemophilia patients (14.6%) and hemodialysis patients (5.2%).3. Among the patients with Non-A, Non-B, Non-C hepatitis, 4 of 83 were positive for GBV-C/HGV RNA and all of them had history of blood transfusion.4. GBV-C/HGV RNA was detected in 11 (0.6%) of 1766 healthy pregnant women.5. GBV-C/HGV RNA was detected in 58 (6.3%) of 916 voluntary blood donors who were positive for hepatitis C virus (HCV) RNA and in 20 (6.3%) of 312 patients with chronic hepatitis treated with interferon. The patients with complete response to interferon were negative for serum HCV RNA but positive for GBV-C/HGV RNA after treatment. Prevalence of GBV-C/HGV infection is low rate in Japan and no relation was found between GBV-C/HGV viremia and clinical sign of hepatitis.

研究了GB病毒C（GBV-C） /丙型肝炎病毒（HGV）的患病率。通过反转录聚合酶链反应测试了从各个组获得的血清样品。1。在输血后非C，非C肝炎的23例患者中，输血后217例血清氨基转移酶水平正常的GBV-C/FIGV RNA呈阳性，6例（2.8％）为GBV-C/HGV RNA阳性。在静脉吸毒者（13.2％），血友病患者（14.6％）和血液透析患者（5.2％）中，GBV-C/HGV RNA的高阳性发生率很高（13.2％）。在非A，非B，非C肝炎的患者中，83例中有4例对GBV-C/HGV RNA呈阳性，并且所有人都有输血史。4。在1766名健康孕妇中，有11名（0.6％）检测到GBV-C/HGV RNA。5。在916名自愿供血者中，有58名（6.3％）在丙型肝炎病毒（HCV）RNA中检测到GBV-C/HGV RNA，在312例用干扰素治疗的慢性肝炎患者中，有20名（6.3％）（6.3％）。对干扰素完全反应的患者对于血清HCV RNA为阴性，治疗后GBV-C/HGV RNA呈阳性。日本GBV-C/HGV感染的患病率很低，GBV-C/HGV病毒血症与肝炎的临床症状之间未发现关系。

项目成果

T.Moriya: Liver diseases(in Japanese). Kokusai-isyo-syuppan, (1997)

T.Moriya：肝脏疾病（日语）。

片山恵子: "Annual Review消化器" 中外医学社, 338 (1997)

片山惠子：《胃肠病学年度评论》中外医学社，338（1997）

片山恵子: "C型肝炎とG型肝炎の疫学" Modern Physician. 17(9). 1057-1059 (1997)

Keiko Katayama：“丙型肝炎和庚型肝炎的流行病学”现代医师 17(9) (1997)。

守屋 尚: "肝臓病" 国際医書出版, 335 (1997)

守谷隆：《肝病》国际医学出版社，335（1997）

守屋尚: "肝臓病" 国際医書出版, 335 (1997)

森谷恒：《肝病》国际医学出版社，335（1997）