Study of Bubble Nuclei Distribution and Bubble Embolism in Plasma Subjected with Variation of Environmental Pressure

环境压力变化下血浆中气泡核分布和气泡栓塞的研究

• 批准号: 09650199
• 负责人: TSUJINO Tomoji
• 金额: $ 1.98万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09650199/
• 关键词: Fluid Mechanics; Bioengineering; Bubble; Bubble Nuclei; Gas Diffusion; Bubble Embolism; Decompression Disease; Submarine Sickness; 気泡寒栓; 人工弁; 血管閉塞; ヘリウムガス; 血漿

It is understood that the gases dissolved in human body under the condition of high pressure produced the bubbles in blood vessels as coming back to the atmosphere from an environment of high pressure, and that decompression disease causes disturbances of peripheral circulation due to bubble embolism. However very little is known about the mechanism.In the present study, as the purpose of clarification of mechanism of an outbreak of decompression disease, the distributions of the bubble nuclei in liquids subjected with the variation of pressure are made clear by the coulter counter method. Test liquids are water, plasma and blood. Test gases are air, carbon dioxide gas, oxygen gas and helium gas.Consequently, it is found that the bubble nuclei with diameter more than 10μ m increase with an increment of the additional gas pressure. The number of bubble nuclei of carbon dioxide gas is the most in the other gases. The nuclei number of helium gas is the least. The number of bubble nuclei in plasma is larger than in water. In blood, the number of bubble nuclei with comparatively large size increases compared with that in water. The number of bubble nuclei in flowing liquids increase more than 1〜4 order of magnitude than the static condition, and the nuclei number increases with an increment of flow velocity. The mechanism of bubble embolism which causes decompression disease is clarified.

可以理解，在高压状态下溶解在人体中的气体会导致血管中的气泡从高压环境中恢复到大气中，而减压疾病会导致气泡栓塞引起的外周流通循环障碍。然而，关于该机制的知之甚少。在本研究中，作为阐明减压疾病爆发机制的目的，该反调子方法清楚地表明了与压力变化的液体中气泡核的分布。测试液体是水，血浆和血液。测试气体是空气，二氧化碳，氧气和氦气气体。结果发现，直径的气泡核随着额外的气压的增加而增加了10μm。二氧化碳气体的气泡核数量是其他气体中最多的。氦气的核数量最少。血浆中气泡核的数量大于水中的气泡数。在血液中，与水中相比，气泡核的数量相对较大。流动液体中气泡核的数量比静态条件增加了1-4个数量级以上，并且核数随流速的增加而增加。阐明了引起减压疾病的气泡栓塞机制。

项目成果

T. Tsujino: "Dissolution of NィイD22ィエD2Bubbles in Blood under Hyperbaric Oxygen Therapy"Memoirs of The Faculty of Education, Kumamoto Univeristy. 47. 81-86 (1998)

T. Tsujino：“高压氧治疗下血液中 D22 气泡的溶解”熊本大学教育学院回忆录 47. 81-86 (1998)。

K. Uranishi and T. Tsujino: "Development of a Micro Turbo Pump"Proc. of JSME Ceternial Grand Cong. Inter. Conf. Fluid Engng.. 857-862 (1997)

K. Uranishi 和 T. Tsujino：“微型涡轮泵的开发”Proc。

K. Uranishi, T. Tsujino, M. Miura: "Development of a Micro Turbo Pump"Proc. Of JSME Caternial Grand Cong. Inter. Conf. Fluid Eng..

K. Uranishi、T. Tsujino、M. Miura：“微型涡轮泵的开发”Proc。

K.Uranishi, T.Tsujino. M.Miura: "Development of a Micro Turbo Pump" Proc.of JSME Ceternicl Grand Cong.Inter.Conf.Fluid Engng. 857-862 (1997)

K.Uranishi，T.Tsujino。

辻野智二・三浦誠・平井和人: "左心補助用大動脈内留置型血液ポンプの試作に関する研究" 日本機械学会第10回バイオエンジニアリング講演論文集. 97-72. 195-196 (1998)

Tomoji Tsujino、Makoto Miura、Kazuto Hirai：“用于左心室辅助的主动脉内血泵原型生产的研究”日本机械工程师学会第十届生物工程会议记录 97-72（1998）。