Molecular Mechanism of Atherosclerosis

动脉粥样硬化的分子机制

基本信息

批准号：
09281103
负责人：
KITA Toru
金额：
$ 128.06万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas (A)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09281103/
关键词：
Atherosclerosis Vascular endothelial cell Vasculogenesis Angiogenesis Vascular smooth muscle cell Phenotypic conversion Adhesion molecule Oxidized LDL リゾフォスファチジルコリン CD36 LOX-1 マクロファージずり応力酸化LDL受容体

项目摘要

The Grants-in-Aid for Scientific Research on Priority Areas No. 09281104 was issued from 1997 to 2000. During the period, we organized a research group with scientists who are considered to be most active in the research field. Atherosclerosis is correlated with a variety of vascular disorders such as coronary heart disease. We therefore placed our goal on elucidation of the molecular mechanism of atherosclerosis and exploration of novel therapeutic strategies. To conduct investigation, the members were divided into 3 subgroups, i.e. Group 1, 2, and 3 with different subject of study as follows. We also formed a Central Committee to coordinate and facilitate the research activity of the subgroups.The Study Group 3 studied endothelial dysfunction and blood cells. There has been accumulating evidence that atherosclerosis is initiated by endothelial dysfunction due to a variety of biological insults. We therefore formed this subgroup to explore the key molecules involved in those events. We discovered novel scavenger receptors such as LOX-1 and SRPSOX. Furthermore, we revealed that adipose tissues produce cytokines abundantly. Among those cytokines, adiponectin has been shown to play an important role in atherogenesis and insulin resistance.In conclusion, we have made a successful progress in atherosclerosis research, which will be translated into clinical application in the near future.

1997年至2000年，我们发放了第09281104号优先领域科学研究资助资金。在此期间，我们组织了一个由该领域最活跃的科学家组成的研究小组。动脉粥样硬化与冠心病等多种血管疾病相关。因此，我们的目标是阐明动脉粥样硬化的分子机制并探索新的治疗策略。为了进行调查，成员被分为 3 个小组，即第 1 组、第 2 组和第 3 组，其研究主题不同，如下。我们还成立了一个中央委员会来协调和促进各小组的研究活动。第三研究组研究内皮功能障碍和血细胞。越来越多的证据表明，动脉粥样硬化是由多种生物损伤导致的内皮功能障碍引发的。因此，我们成立了这个小组来探索这些事件中涉及的关键分子。我们发现了新型清道夫受体，例如 LOX-1 和 SRPSOX。此外，我们发现脂肪组织大量产生细胞因子。在这些细胞因子中，脂联素已被证明在动脉粥样硬化和胰岛素抵抗中发挥着重要作用。总之，我们在动脉粥样硬化研究方面取得了成功的进展，并将在不久的将来转化为临床应用。