Development of an electrochemical biosensor for psychoactive metabolites of marijuana

开发用于大麻精神活性代谢物的电化学生物传感器

• 批准号: 506992-2016
• 负责人: MacCallum, Justin
• 金额: $ 5.46万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Collaborative Research and Development Grants
• 财政年份: 2018
• 资助国家: 加拿大
• 起止时间: 2018-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=658212
• 关键词: Development; electrochemical; biosensor; psychoactive; metabolites

Impaired driving remains an unfortunately common occurrence with a major impact on Canadians. The rate of drunk driving has steadily fallen since the mid-1980s, driven in part by the development of rapid, reliable, and portable breath alcohol testing devices. However, estimates suggest that, during weekends, up to 20 percent of drivers are impaired due to the use of recreational or prescription drugs, for which there are currently no practical roadside tests. This is a particularly relevant challenge now due to the impending legalization of marijuana in Canada.****This proposal addresses the pressing need to develop a roadside marijuana sensor. The project combines the sensitivity afforded by optimized electrochemistry with the exquisite specificity of protein engineering. Our industrial partner, Alcohol Countermeasure Systems (ACS), is a world-leader in the development of alcohol breath sensors. The development of a sensitive, specific roadside test for marijuana would would provide law enforcement with new tools to ensure the safety of Canada's roads and would establish ACS and Canada as an international leader in this emerging sector.******

不幸的是，不清醒驾驶仍然是一种常见现象，对加拿大人产生了重大影响。自 20 世纪 80 年代中期以来，醉酒驾驶率稳步下降，部分原因是快速、可靠和便携式呼气酒精测试设备的发展。然而，据估计，周末期间，多达 20% 的驾驶员因使用消遣性药物或处方药而受到伤害，而目前尚无实际的路边测试。由于加拿大即将实现大麻合法化，这是一个特别相关的挑战。****该提案解决了开发路边大麻传感器的迫切需要。该项目将优化电化学提供的灵敏度与蛋白质工程的精致特异性结合起来。我们的工业合作伙伴酒精对策系统 (ACS) 是酒精呼吸传感器开发领域的世界领先者。开发敏感、具体的大麻路边测试将为执法部门提供新工具，以确保加拿大道路的安全，并使 ACS 和加拿大成为这一新兴领域的国际领导者。******