Role of TRPM7 and TRPM2 Channels in Neuronal Development and Regeneration

TRPM7 和 TRPM2 通道在神经元发育和再生中的作用

• 批准号: RGPIN-2016-04574
• 负责人: Sun, HongShuo
• 金额: $ 2.26万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2017
• 资助国家: 加拿大
• 起止时间: 2017-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=630526
• 关键词: Role; TRPM7; TRPM2; Channels; Neuronal

Neurons are highly specialized cells that form the basic functional units in brain circuitry, and proper development of neuronal structure and circuitry is essential for normal function of the brain. We propose to investigate the role of Transient Receptor Potential (TRP) channels in neuronal development and regeneration with specific interest in TRPM7 and its closely related TRPM2 channels. TRPM7 and TRPM2 are non-selective cation channels permeable to Ca

神经元是高度特化的细胞，形成大脑回路的基本功能单元，神经元结构和回路的正确发育对于大脑的正常功能至关重要。我们建议研究瞬时受体电位 (TRP) 通道在神经元发育和再生中的作用，特别关注 TRPM7 及其密切相关的 TRPM2 通道。 TRPM7 和 TRPM2 是可渗透 Ca 的非选择性阳离子通道