Analysis of GADD34 deficiency effects on obesity-inducetype 2 diabetes and fatty liver development with the aging

GADD34缺乏对肥胖诱发的2型糖尿病和脂肪肝随年龄增长的影响分析

• 批准号: 26870257
• 负责人: NISHIO Naomi
• 金额: $ 2.41万
• 依托单位: Nagoya City University (2015-2016)Nagoya University (2014)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-26870257/
• 关键词: GADD34; 老化; 脂肪肝; インスリンシグナル伝達系; 炎症; Insulin/IGF1レセプターシグナル伝達系; 細胞膜タンパク質; 免疫; 代謝; 脂肪肝形成; 高脂肪食摂取

项目成果

Murine model of obesity-induced type II diabetes by GADD34(PPP1R15A) and other phosphatase 1 regulatory subunits deficiency.

GADD34(PPP1R15A) 和其他磷酸酶 1 调节亚基缺陷导致肥胖诱发 II 型糖尿病的小鼠模型。

• 发表时间: 2016
• 期刊: SDRP Journal of Infectious Diseases Treatement & Therapy,
• 作者: Ken-ichi Isobe;Naomi Nishio;Tadao Hasegawa.
• 通讯作者: Tadao Hasegawa.

GADD34 works to suppress obesity-induced MetabolicDiseases including type 2 diabetes and NASH

GADD34 致力于抑制肥胖引起的代谢疾病，包括 2 型糖尿病和 NASH

• 发表时间: 2014
• 作者: Naomi Nishio;Sachiko Ito and Ken-ich isobe
• 通讯作者: Sachiko Ito and Ken-ich isobe

Reprint of "iPSCs, aging and age-related diseases".

• DOI: 10.1016/j.nbt.2014.11.002
• 发表时间: 2015-01
• 期刊: New biotechnology
• 影响因子: 5.4
• 作者: K. Isobe;Zhao Cheng;N. Nishio;T. Suganya;Yuriko Tanaka;S. Ito

GADD34 works to suppress obesity-induced metabolic disease including type 2 diabetes and NASH-2

GADD34 致力于抑制肥胖引起的代谢疾病，包括 2 型糖尿病和 NASH-2

• 发表时间: 2015
• 作者: Naomi Nishio;Tadao Hasegawa and Ken-ich Isobe.;澤 正憲;Naomi Nishio and Ken-ich Isobe
• 通讯作者: Naomi Nishio and Ken-ich Isobe

Thymic Epithelial Cells Induced from Pluripotent Stem Cells by a Three-Dimensional Spheroid Culture System Regenerates Functional T Cells in Nude Mice.

通过三维球体培养系统从多能干细胞诱导胸腺上皮细胞在裸鼠中再生功能性 T 细胞。

• DOI: 10.1089/cell.2015.0006
• 发表时间: 2015
• 期刊: Cell Reprogramming
• 作者: 41. Okabe Motohito;Sachiko Ito;Naomi Nishio; Yuriko Tanaka and Ken-ichi Isobe
• 通讯作者: Yuriko Tanaka and Ken-ichi Isobe