Therapeutic strategy to target epithelial stem cell specific epigenetic regulation

针对上皮干细胞特异性表观遗传调控的治疗策略

• 批准号: 17K16332
• 负责人: hazawa masaharu
• 金额: $ 2.75万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17K16332/
• 关键词: 核膜孔複合体; エピジェネティクス; 腫瘍生物学; 分子細胞生物学; 扁平上皮癌; 遺伝子発現; 上皮分化; 皮膚組織幹細胞; 癌; 遺伝子; ゲノム; 細胞・組織

项目成果

Nucleoporin TPR (translocated promoter region, nuclear basket protein) upregulation alters MTOR-HSF1 trails and suppresses autophagy induction in ependymoma.

• DOI: 10.1080/15548627.2020.1741318
• 发表时间: 2021-04
• 期刊: Autophagy
• 影响因子: 13.3
• 作者: Dewi FRP;Jiapaer S;Kobayashi A;Hazawa M;Ikliptikawati DK;Hartono;Sabit H;Nakada M;Wong RW
• 通讯作者: Wong RW

Nuclear transport system caused by disease-specific Karyopherin alternation

疾病特异性核传递蛋白交替引起的核运输系统

• 发表时间: 2018
• 作者: Sakai K;Hazawa M;Kobayashi A;Wong RW.
• 通讯作者: Wong RW.

Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines

• DOI: 10.3390/cancers12040908
• 发表时间: 2020-04-01
• 期刊: CANCERS
• 影响因子: 5.2
• 作者: Hazawa, Masaharu;Yoshino, Hironori;Kashiwakura, Ikuo
• 通讯作者: Kashiwakura, Ikuo

Disease-specific alteration of karyopherin-α subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma

• DOI: 10.1038/s41388-019-1137-3
• 发表时间: 2020-03-01
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Hazawa, Masaharu;Sakai, Kie;Wong, Richard W.
• 通讯作者: Wong, Richard W.

Direct visualization of avian influenza H5N1 hemagglutinin precursor and its conformational change by high-speed atomic force microscopy

• DOI: 10.1016/j.bbagen.2019.02.015
• 发表时间: 2020-02-01
• 期刊: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
• 影响因子: 3
• 作者: Lim, Kee Siang;Mohamed, Mahmoud Shaaban;Wong, Richard W.
• 通讯作者: Wong, Richard W.