Identification of novel biomarkers and therapeutic targets for refractory malignant solid tumors by comprehensive omics analyses

通过综合组学分析鉴定难治性恶性实体瘤的新型生物标志物和治疗靶点

• 批准号: 17K15038
• 负责人: Kawabata Reika
• 金额: $ 2.83万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17K15038/
• 关键词: 肺がん; トリプルネガティブ乳がん; 予後予測マーカー; 治療標的; RNA-seq; 新規治療標的; 免疫組織染色; バイオマーカー; 小細胞肺がん; 肺扁平上皮がん; 化学療法耐性機構; 癌; ゲノム; 遺伝子

项目成果

STXBP4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma.

• DOI: 10.1158/1078-0432.ccr-16-1815
• 发表时间: 2017-07-01
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Otaka Y;Rokudai S;Kaira K;Fujieda M;Horikoshi I;Iwakawa-Kawabata R;Yoshiyama S;Yokobori T;Ohtaki Y;Shimizu K;Oyama T;Tamura J;Prives C;Nishiyama M
• 通讯作者: Nishiyama M

Myeloid sarcoma arising in malignant phyllodes tumour: clonal relationships revealed by comparative genome-wide analyses

恶性叶状肿瘤中出现的骨髓肉瘤：通过比较全基因组分析揭示的克隆关系

• DOI: 10.1111/bjh.14539
• 发表时间: 2017
• 期刊: British Journal of Haematology
• 影响因子: 6.5
• 作者: Arai Hideo;Nobusawa Sumihito;Kawabata-Iwakawa Reika;Rokudai Susumu;Higuchi Toru;Yamazaki Tatsuya;Horiguchi Jun;Sano Takaaki;Kojima Masaru;Nishiyama Masahiko;Yokoo Hideaki;Hirato Junko;Oyama Tetsunari
• 通讯作者: Oyama Tetsunari

Caspase14 expression is associated with triple negative phenotypes and cancer stem cell marker expression in breast cancer patients

• DOI: 10.1002/jso.24705
• 发表时间: 2017-11-01
• 期刊: JOURNAL OF SURGICAL ONCOLOGY
• 影响因子: 2.5
• 作者: Handa, Tadashi;Katayama, Ayaka;Oyama, Tetsunari
• 通讯作者: Oyama, Tetsunari

Next-Generation Sequencing and Bioinformatics

下一代测序和生物信息学

• DOI: 10.1007/978-981-10-2002-5_6
• 发表时间: 2017
• 期刊: Molecular Targeted Therapy of Lung Cancer
• 作者: Kawabata-Iwakawa Reika;Bono Hidemasa;Nishiyama Masahiko
• 通讯作者: Nishiyama Masahiko

Significantly mutated genes and regulatory pathways in SCLC-a meta-analysis.

• DOI: 10.1016/j.cancergen.2017.05.003
• 发表时间: 2017-10
• 期刊: Cancer genetics
• 影响因子: 1.9
• 作者: Sundaresan V;Lin VT;Liang F;Kaye FJ;Kawabata-Iwakawa R;Shiraishi K;Kohno T;Yokota J;Zhou L
• 通讯作者: Zhou L