Translational research to evaluate the resistant mechanism of anti-HER2 antibody by using immunohistochemistry and next-generation sequencing in HER2-positive gastric patients.

利用免疫组织化学和新一代测序评估 HER2 阳性胃病患者抗 HER2 抗体耐药机制的转化研究。

• 批准号: 17K15010
• 负责人: Takahashi Naoki
• 金额: $ 2.16万
• 依托单位: Research Institute for Clinical Oncology, Saitama Cancer Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17K15010/
• 关键词: 胃癌; HER2; ハーセプチン; trastuzumab; gastric cancer; HER2陽性胃癌; 免疫染色; 次世代シークエンサー

项目成果

Safety, tolerability and pharmacokinetics of the fibroblast growth factor receptor inhibitor AZD4547 in Japanese patients with advanced solid tumours: a Phase I study.

• DOI: 10.1007/s10637-016-0416-x
• 发表时间: 2017-08
• 期刊: Investigational new drugs
• 影响因子: 3.4
• 作者: Saka H;Kitagawa C;Kogure Y;Takahashi Y;Fujikawa K;Sagawa T;Iwasa S;Takahashi N;Fukao T;Tchinou C;Landers D;Yamada Y
• 通讯作者: Yamada Y

Asymptomatic Pancreatic Metastasis from Renal Cell Carcinoma Diagnosed 21 Years after Nephrectomy.

• DOI: 10.1155/2017/8765264
• 发表时间: 2017
• 期刊: Case reports in gastrointestinal medicine
• 影响因子: 0.7
• 作者: Zianne M;Takahashi N;Tsujibata A;Miwa K;Goto Y;Matano Y
• 通讯作者: Matano Y

Genome-wide Discovery and Identification of a Novel miRNA Signature for Recurrence Prediction in Stage II and III Colorectal Cancer.

• DOI: 10.1158/1078-0432.ccr-17-3236
• 发表时间: 2018-08-15
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Kandimalla R;Gao F;Matsuyama T;Ishikawa T;Uetake H;Takahashi N;Yamada Y;Becerra C;Kopetz S;Wang X;Goel A
• 通讯作者: Goel A

AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer

• DOI: 10.1172/jci.insight.99976
• 发表时间: 2018-06-21
• 期刊: JCI INSIGHT
• 影响因子: 8
• 作者: Shigeyasu, Kunitoshi;Okugawa, Yoshinaga;Goel, Ajay
• 通讯作者: Goel, Ajay

Comparison of HER2 expression by immunohistochemistry and HER2 copy number by digital PCR in tumor tissue during treatment with trastuzumab in the prospective cohort of metastatic HER2-positive gastric cancer patients.

在转移性 HER2 阳性胃癌患者前瞻性队列中，使用曲妥珠单抗治疗期间肿瘤组织中免疫组织化学检测的 HER2 表达和数字 PCR 检测的 HER2 拷贝数的比较。

• 发表时间: 2019
• 作者: Naoki Takahashi;Satoru Iwasa;Tomohiro Matsushima;Shoichi Miyazawa;Satoshi Shimizu;Yosuke Kumekawa;Takako Yoshii;Masako Asayama;Hiroki Hara.
• 通讯作者: Hiroki Hara.