Brain function for salt homeostasis

盐稳态的大脑功能

• 批准号: 17024056
• 负责人: NODA Masaharu
• 金额: $ 34.24万
• 依托单位: National Institute for Basic Biology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17024056/
• 关键词: 細胞・組織; 神経科学; 脳・神経; 生理学; 体液恒常性; 体液塩濃度; 塩分・水分摂取; Naチャンネル; ナトリウムセンサー; グリア細胞

Na_x channels are localized to the circumventricular organs (CVOs), the control loci for the salt and water homeostasis in mammals, where the Nax channel serves as a sodium-level sensor of body fluids. Now findings obtained in the research period are as follows.(1) Na_x is exclusively localized to perineuronal lamellate processes extended from ependymal cells and astrocytes in CVOs.(2) Astrocytes in the subfornical organ (SFO), one of the CVOs, sense an increase in the extracellular [Na^+] and moderate the activity of local neurons by using lactate as a signal.(3) The information of [Na^+] increase detected by Nax does not contribute to the control of vasopressin production/release.(4) We identified a case with clinical features of "essential hypernatremia", who was diagnosed as a paraneoplastic neurologic disorder. Anti-Na_x autoantibodies were found in the patient serum, and mice injected with the patient's Ig showed symptoms of "essential hypernatremia".

Na_x通道位于室内器官（CVO），这是哺乳动物中盐和水稳态的控制基因座，NAX通道是体液的钠级传感器。现在在研究期间获得的发现如下。（1）Na_x仅定位于CVOS中的室心膜细胞和星形胶质细胞延伸到室内神经元层状过程。（2）副异端器官（SFO）中的星形胶质细胞（SFO），cvos之一，cvos a之一，cvos a cvos a cvos a cvos a cvos a cvos。通过使用乳酸作为信号来增加细胞外[Na^+]的增加，并通过使用乳酸来缓解局部神经元的活性。（3）NAX检测到的[Na^+]增加的信息并不能导致控制加压素的产生/释放。 （4）我们确定了具有“必需高钠血症”的临床特征的病例，该病例被诊断为副塑性神经系统疾病。在患者血清中发现了抗NA_X自身抗体，注射患者IG的小鼠显示出“必需的高钠血症”的症状。

项目成果

Tyrosine phosphorylation of ErbB4 is enhanced by PSD95 and repressed by protein tyrosine phosphatase receptor type Z

• DOI: 10.1093/jb/mvm140
• 发表时间: 2007-09-01
• 期刊: JOURNAL OF BIOCHEMISTRY
• 影响因子: 2.7
• 作者: Fujikawa, Akihiro;Chow, Jeremy Pak Hong;Noda, Masaharu
• 通讯作者: Noda, Masaharu

The subfornical organ, a specialized sodium channel, and the sensing of sodium levels in the brain

• DOI: 10.1177/1073858405279683
• 发表时间: 2006-02-01
• 期刊: NEUROSCIENTIST
• 影响因子: 5.6
• 作者: Noda, M

Plasmin-mediated processing of protein tyrosine phosphatase receptor type Z in the mouse brain

• DOI: 10.1016/j.neulet.2008.07.028
• 发表时间: 2008-09-19
• 期刊: NEUROSCIENCE LETTERS
• 影响因子: 2.5
• 作者: Chow, Jeremy Pak Hong;Fujikawa, Akihiro;Noda, Masaharu
• 通讯作者: Noda, Masaharu

A [Na+] dependent metabolostat in the subfornical organ to control salt intake.

穹窿下器官中的[Na ]依赖性代谢调节剂可控制盐的摄入量。

• 发表时间: 2009
• 作者: Morrow;E.M.;Fujikawa et al.;佐藤 茂;Shintani et al.;野田昌晴;野田昌晴;Noda M
• 通讯作者: Noda M

Eph receptors are negatively regulated by protein tyrosine phosphatase receptor type O.

Eph 受体受 O 型蛋白酪氨酸磷酸酶受体负调节。

• 发表时间: 2007
• 作者: Shintani T;他5名6番目
• 通讯作者: 他5名6番目