Roles of transcription factors for carcinogenesis and carcinogenesisdefense

转录因子在癌发生和癌发生防御中的作用

• 批准号: 17013017
• 负责人: MASAYUKI Yamamoto
• 金额: $ 79.36万
• 依托单位: Tohoku University (2007-2009)University of Tsukuba (2005-2006)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17013017/
• 关键词: 転写因子; 発癌; 癌抑制; 多段階発がん; GATA1; 白血病幹細胞; 幹細胞性; 治療抵抗性; 巨核芽球白血病; ダウン症候群; 一過性骨髄増殖症; 前赤芽球性性白血病; 質的異常; 量的異常; GATA-1; GATA-2; Nrf2; Keap1造血; 白血病; 酸化ストレス; 遺伝子改変マウス

In this study, we investigated roles transcription factors play on carcinogenesis and carcinogenesis defense in vivo, focusing on the Nrf2 and GATA transcription factors. We have found that co-operative function of Nrf2 and Keap1, which mediates cellular stress response, is important for the cancer carcinogenesis defense so that the failure in Nrf2-Keap1 system leads to the onset of cancer and poor prognosis. We have further found that deregulated function of GATA factors, which act as key molecules in hematopoietic homeostasis, causes leukemogenesis.

在本研究中，我们研究了转录因子在体内致癌和致癌防御中的作用，重点关注 Nrf2 和 GATA 转录因子。我们发现Nrf2和Keap1介导细胞应激反应的协同功能对于癌症的致癌防御非常重要，因此Nrf2-Keap1系统的故障导致癌症的发生和不良预后。我们进一步发现，作为造血稳态关键分子的 GATA 因子的功能失调会导致白血病发生。

项目成果

GATA factor switching during erythroid differentiation

红细胞分化过程中的 GATA 因子转换

• DOI: 10.1097/moh.0b013e32833800b8
• 发表时间: 2010-05-01
• 期刊: CURRENT OPINION IN HEMATOLOGY
• 影响因子: 3.2
• 作者: Kaneko, Hiroshi;Shimizu, Ritsuko;Yamamoto, Masayuki
• 通讯作者: Yamamoto, Masayuki

Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress

• DOI: 10.1007/s12012-008-9016-0
• 发表时间: 2008-06-01
• 期刊: CARDIOVASCULAR TOXICOLOGY
• 影响因子: 3.2
• 作者: Zhu, Hong;Jia, Zhenquan;Li, Yunbo
• 通讯作者: Li, Yunbo

Nrf2 transcriptionally activates the mafG gene through an antioxidant response element

• DOI: 10.1074/jbc.m411451200
• 发表时间: 2005-02-11
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Katsuoka, F;Motohashi, L;Yamamoto, M
• 通讯作者: Yamamoto, M

Regulation of adipocyte differentiation of bone marrow stromal cells by transcription factor GATA-2.

• DOI: 10.1016/j.bbrc.2007.10.031
• 发表时间: 2007-12
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Y. Okitsu;Shinichirou Takahashi;N. Minegishi;J. Kameoka;M. Kaku;Masayuki Yamamoto;Takeshi Sasaki;H. Harigae

Hyperglycemia induces oxidative and nitrosative stress and increases renal functional impairment in Nrf2-deficient mice

• DOI: 10.1111/j.1365-2443.2008.01234.x
• 发表时间: 2008-11-01
• 期刊: GENES TO CELLS
• 影响因子: 2.1
• 作者: Yoh, Keigyou;Hirayama, Aki;Yamamoto, Masayuki
• 通讯作者: Yamamoto, Masayuki