the maintenance and circulation of protein higher-order structural information and the evaluation of prediction information

蛋白质高阶结构信息的维护和循环以及预测信息的评估

基本信息

批准号：
12207002
负责人：
GO Mitiko
金额：
$ 50.24万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12207002/
关键词：
Computational biology Bioinformatics Genome function prediction Protein structure prediction Critical Assessment of Techniques for Protein Structure Prediction Homology modeling FAMSBASE Molecular simulation CASP5 シミュレーションアブイニシオ予測生

项目摘要

Mainly through the following research products and activities for three years, we conducted the maintenance and circulation of protein higher-order structural information and the evaluation of prediction information.Every year we held the open workshop of "Genome Information Science Based on Protein Higher-order Structures (Higher-order Genome)", including poster presentations of the "Higher-order Genome" group and a one-day symposium. In the first year, we invited two overseas speakers from the field of protein architecture and bioinformatics and held an international symposium. In the second year, in preparation for coming days of higher-order structural information flood according to rapid progress of the structural genomics, we held the open symposium titled "Information Biology as Structural Genome Science--When All Protein Structures of the Representative Proteins Are Clarified--", enhancing cooperation with structural biologists. Decoding of genome information would be incomplet … More e without understanding of proteins, main actors playing direct roles for physiological phenomena, and simulation studies are occupying an important position as a means for that aim. In the third year, we thus held the international symposium titled "Frontier Bioinformatics--To What Extent Can Simulations Clarify Protein Functions?", where four overseas researchers were invited."One-day symposium of computational structural genomics" was also held as a satellite meeting of "International Conference on Structural Genomics (ICSG) in 2000. Additionally, we executed various activities including research meetings of the "Higher-order Genome" group, support of young researcher's study meetings, travel support to attend the international meeting of "Critical Assessment of Techniques for Protein Structure Prediction (CASP)" and cooperation with alga researchers in "Genome Biology".On the other hand, we constructed as complete sets of comparative protein structure models as possible for the whole genome ORFs presented in GTOP database and publicly released as FAMSBASE (http://daisy.nagahama-i-bio.ac.jp/Famsbase/). A statistical analysis of the data was also published. Less

主要通过以下研究产品和活动已有三年了，我们进行了蛋白质高阶结构信息的维护和循环，并评估预测信息。每个年份，我们举行了开放的“基于蛋白质高阶结构（高阶基因组）的基因组信息科学的开放研讨会”，包括“高级基因组”组的海报介绍。在第一年，我们邀请了来自蛋白质建筑和生物信息学领域的两名海外发言人，并举行了国际研讨会。第二年，为了准备接下来的高阶结构信息，根据结构基因组学的快速发展，我们举行了题为“信息生物学作为结构性基因组科学的信息生物学）的开放式研讨会，当澄清了代表性蛋白的所有蛋白质结构 - 澄清了 - 增强与结构生物学家的合作。基因组信息的解码将是不完整的……更多不理解蛋白质，主要参与者在物理现象中扮演直接作用，模拟研究正占据重要的位置，作为该目标的手段。因此，在第三年，我们举行了国际研讨会，标题为“边境生物信息学 - 至今可以阐明蛋白质功能？”，邀请了四个海外研究人员。”一日计算结构基因组学研讨会也被视为“卫星卫星”的“国际结构基因组学（ICSG）的卫星会议”。对年轻研究人员的研究会议的支持，旅行支持参加国际会议“蛋白质结构预测技术的批判性评估”（CASP）的批判性评估”以及与“基因组生物学”中的藻类研究人员的合作。在另一方面，我们作为在GTOP数据库和FAMS中呈现的整个基因组ORF的完整蛋白质结构模型构建（http://daisy.nagahama-i-bio.ac.jp/famsbase/）。还发布了对数据的统计分析。较少的