Novel enantioselective routes to molecules posessing planar, helical and axial chirality

具有平面、螺旋和轴向手性分子的新型对映选择性途径

• 批准号: 298386-2010
• 负责人: Collins, Shawn
• 金额: $ 3.64万
• 依托单位: Université de Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2014
• 资助国家: 加拿大
• 起止时间: 2014-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=548323
• 关键词: Novel; enantioselective; routes; molecules; posessing

Chirality is a property of molecules that has an extraordinary impact on living beings. The use of asymmetric catalysis to prepare molecules having tetrahedral chirality has had an enormous impact on the pharmaceutical industry. Recently, molecules having alternative forms of chirality has been found to be equally as interesting for medicinal chemistry and possess interesting properties that can be exploited in nanoscience, materials science, and catalysis. Surprisingly, the development of new enantioselective strategies to access these molecules remains underdeveloped. The current proposal outlines the development of new synthetic technologies to prepare molecules possessing elements of planar, axial or helical chirality. Molecules possessing these types of chirality are highly valued due to their inherently well defined asymmetric steric environment and interesting optical properties. By developing new syntheses of these chiral molecules using advanced synthetic methods such as asymmetric catalysis, we can access new biologically active molecules and new organic materials.

手性是分子的一种特性，对生物具有非凡的影响。 使用不对称催化制备具有四面体手性的分子对制药工业产生了巨大影响。 最近，人们发现具有其他手性形式的分子对于药物化学同样有趣，并且具有可在纳米科学、材料科学和催化中利用的有趣特性。 令人惊讶的是，获取这些分子的新对映选择性策略的开发仍然不发达。 目前的提案概述了新合成技术的开发，以制备具有平面、轴向或螺旋手性元素的分子。 具有这些类型手性的分子由于其固有的明确的不对称空间环境和有趣的光学特性而受到高度重视。 通过使用先进的合成方法（例如不对称催化）开发这些手性分子的新合成方法，我们可以获得新的生物活性分子和新的有机材料。