From shape to function: how structured RNA defines insect flaviviruses

从形状到功能：RNA结构如何定义昆虫黄病毒

• 批准号: DP240102506
• 负责人: Prof Alexander Khromykh
• 金额: $ 44.16万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102506
• 关键词: shape; function; how; structured; RNA

The goal of this project is to obtain an understanding of how insect-specific flaviviruses (ISFs) utilise viral noncoding RNAs to enable their replication in mosquitoes. These viruses only replicate in mosquitoes, and not in humans or animals. They can be employed as the biocontrol agents for mosquito-borne diseases as they make mosquitoes incapable of disease transmission. However, it is currently unknown how exactly insect-specific flaviviruses affect mosquitoes and this information is vital for informed design of ISF-based interventions. The project will generate new knowledge on functions of noncoding RNAs in ISFs that are hypothesised to have immunomodulatory role in mosquitoes. It will also train students and ECRs.

该项目的目标是了解昆虫特异性黄病毒 (ISF) 如何利用病毒非编码 RNA 使其在蚊子中复制。这些病毒仅在蚊子中复制，而不在人类或动物中复制。它们可以用作蚊媒疾病的生物防治剂，因为它们使蚊子无法传播疾病。然而，目前尚不清楚昆虫特异性黄病毒究竟如何影响蚊子，这一信息对于基于 ISF 的干预措施的知情设计至关重要。该项目将产生关于 ISF 中非编码 RNA 功能的新知识，这些非编码 RNA 被假设对蚊子具有免疫调节作用。它还将培训学生和 ECR。