Study for regulatory mechanism for atrophy of tongue and masticatory muscles by the system of model mouse

模型小鼠系统研究舌及咀嚼肌萎缩的调节机制

• 批准号: 16591871
• 负责人: YAMASE Akira
• 金额: $ 1.98万
• 依托单位: Tsurumi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591871/
• 关键词: atrophy; hypertrophy; masseter; tongue; growth factors; synaptogenesis; muscle satellite cell; muscle dystrophy; IGF; IGFR; 咬筋; 腓腹筋; Klothoマウス; 老化; モデルマウス; 小眼球症マウス; mitf遺伝子; AChR除去; AChR転換; 咀嚼; Miマウス

The following new findings were obtained in the present study.1. The regulatory program for myogenesis of tongue is similar to that for limb myogenesis other than head myogenesis.2. Myogenesis and synaptogenesis in the masticatory muscles are delayed in comparison with other muscles and are not completed even at birth, whereas the development of tongue muscles proceeds faster than those of other muscles and ends at around birth.3. Insulin-like growth factors, their receptors and binding proteins are involved in the atrophy of mouse masseter muscle induced by the transition from hard to soft diets.4. The pool size of satellite cells in the masseter muscle is greater than those in other muscles such as gastrocnemius, soleus and diaphragm muscles of mdx mouse and the pool size is one factor for determining the extent of myofiber degeneration.5. Transforming growth factor β_8 and myostatin function as negative regulators for the hypertrophy induced by clenbuterol, a β_2 adrenergic agonist, whereas Insulin-like growth factors work as positive regulators.

本研究获得以下新发现： 1．舌肌发生的调节程序与除头部肌发生外的四肢肌发生相似。2．咀嚼肌的肌发生和突触发生较其他肌肉延迟且较慢。即使在出生时也未完成，而舌头肌肉的发育比其他肌肉更快，并在出生前后结束。 3．胰岛素样生长因子，其受体和结合蛋白参与了胰岛素样生长因子引起的小鼠咬肌萎缩。过渡4. mdx小鼠咬肌中卫星细胞池的大小大于腓肠肌、比目鱼肌和膈肌等其他肌肉，池大小是决定肌纤维变性程度的因素之一。 .5. 转化生长因子 β_8 和肌肉生长抑制素作为克仑特罗（一种 β_2 肾上腺素能激动剂）诱导的肥大的负调节剂，而胰岛素样生长因子起到正调节作用。

项目成果

Progress of cell proliferation in striated muscle tissues during the development of mouse tongue

小鼠舌头发育过程中横纹肌组织细胞增殖的进展

• 发表时间: 2004
• 期刊: J. Dent. Res. 83(12) : 926-929,2004 83(12)
• 作者: NAGATA;J.;YAMANE;A
• 通讯作者: A

Change from a hard to soft diet alters the expression of insulin-like growth factors, their receptors, and binding proteins in association with atrophy in adult mouse masseter muscle

从硬饮食到软饮食的改变会改变与成年小鼠咬肌萎缩相关的胰岛素样生长因子、其受体和结合蛋白的表达

• 发表时间: 2004
• 期刊: Cell Tissue Res. 315(1)
• 作者: URUSHIYAMA;T.;AKUTSU;S.;MIYAZAKI;J.-I.;FUKUI;T.;DIEKWISCH.T.G.H.;YAMANE.A
• 通讯作者: YAMANE.A

The expressions of insulin-like growth factors, their receptors, and binding proteins are related to the mechanism regulating masseter muscle mass in the rat

• DOI: 10.1016/j.archoralbio.2006.01.003
• 发表时间: 2006-07-01
• 期刊: ARCHIVES OF ORAL BIOLOGY
• 影响因子: 3
• 作者: Matsumoto, T.;Akutsu, S.;Yamane, A.
• 通讯作者: Yamane, A.

Effects of exogenous bone morphogenetic protein 2 on the formation of mouse molar tooth germ

外源骨形态发生蛋白2对小鼠磨牙牙胚形成的影响

• 发表时间: 2004
• 期刊: Journal of Oral Biosciences 46・6
• 作者: T.Fukui;et al.
• 通讯作者: et al.

口腔組織発生における肝細胞増殖因子の機能

肝细胞生长因子在口腔组织发育中的作用

• 发表时间: 2004
• 期刊: 口腔組織培養学会誌 13・2
• 作者: 天野 修;山根 明
• 通讯作者: 山根 明