Electrophysiology of the pulmonary vein in the left atrial volume-load model

左心房容量负荷模型中肺静脉的电生理学

• 批准号: 16591418
• 负责人: NITTA Takashi
• 金额: $ 1.98万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16591418/
• 关键词: Atrial fibrillation; Pulmonary vein; Volume load; Left atrium

Electrophysiology of the pulmonary veins in a left atrial volume-load model was studied. A shunt was made between the left subclavian artery and the left pulmonary artery in mongrel dogs. All the animals exhibited severe heart failure postoperatively. Some animals died of severe heart failure. The animals survived for 4 weeks were subjected to the pulmonary vein mapping study. Conduction velocity of the pulmonary veins was measured during pacing by means of custom-made a multi-electrode catheter. Data were compared with those obtained from the normal control animals. Diameter of each pulmonary vein was measured and myocardium sleeve extending into the pulmonary veins was examined microscopically.The conduction velocity decreased in the circumferential direction of the pulmonary veins in the volume-loaded animals. The change of the conduction velocity in the longitudinal direction varied and there was no significant difference between the control animals. Histological examination revealed that the myocardial sleeve was stretched and thinned in the circumferential direction. Fibrosis was also present. It remains uncertain whether the decrease in the conduction velocity was due to true decrease in the conduction velocity or increase of the caliber of the pulmonary vein.

研究了左心房容量负荷模型中肺静脉的电生理学。在杂种狗的左锁骨下动脉和左肺动脉之间进行分流。所有动物术后均表现出严重的心力衰竭。有些动物死于严重的心力衰竭。对存活4周的动物进行肺静脉标测研究。在起搏期间通过定制的多电极导管测量肺静脉的传导速度。将数据与从正常对照动物获得的数据进行比较。测量各肺静脉的直径，并在显微镜下检查延伸到肺静脉中的心肌袖。在容量负荷动物中，传导速度沿肺静脉周向降低。纵向传导速度的变化各不相同，对照组动物之间没有显着差异。组织学检查发现心肌袖沿周向拉伸变薄。还存在纤维化。目前尚不确定传导速度的降低是由于传导速度的真正降低还是肺静脉管径的增加所致。

项目成果

心臓外科(新井達太、編)

心脏外科（新井龙太编辑）

• 发表时间: 2005
• 作者: Isomatsu Y;Shin'oka T;Aoki M;Terada M;Takeuchi T;Hoshino S;Takanashi Y;Imai Y;Kurosawa H;新田 隆;Shin'oka T;新田 隆
• 通讯作者: 新田 隆

Surgery for atrial fibrillation.

• DOI: 10.1016/j.ccl.2014.07.003
• 发表时间: 2014-11
• 期刊: Cardiology clinics
• 影响因子: 2.4
• 作者: Lawrance CP;Henn MC;Damiano RJ Jr
• 通讯作者: Damiano RJ Jr

Manual of Surgical Treatment of atrial fibrillation (Ed : Dr Sie, Dr D'Ancona, Dr Bartolozzi, Dr Beukema, Dr Doty)

心房颤动手术治疗手册（编者：Dr Sie、Dr DAncona、Dr Bartolozzi、Dr Beukema、Dr Doty）

• 作者: Isomatsu Y;Shin'oka T;Aoki M;Terada M;Takeuchi T;Hoshino S;Takanashi Y;Imai Y;Kurosawa H;新田 隆;Shin'oka T;新田 隆;Toshiharu Shin'oka;Nitta T
• 通讯作者: Nitta T

新目でみる循環器病シリーズ(小川 聡、編)

新视角下的心血管疾病系列（小川聪主编）

• 发表时间: 2005
• 作者: Nitta T;et al.;新田 隆;Shin'oka T;新田 隆
• 通讯作者: 新田 隆

心臓外科Knack & Pitfalls : 弁膜症外科の要点と盲点(高本眞一監修、四津良平、編)

心脏手术的窍门与陷阱：瓣膜手术的要点与盲点（高本新一、四津良平主编）

• 发表时间: 2005
• 作者: Isomatsu Y;Shin'oka T;Aoki M;Terada M;Takeuchi T;Hoshino S;Takanashi Y;Imai Y;Kurosawa H;新田 隆
• 通讯作者: 新田 隆