Relation of the postmortem elapsed time in alcohol and stimulants compound intoxication, and a drug level.

酒精和兴奋剂化合物中毒的死后时间与药物水平的关系。

• 批准号: 16590547
• 负责人: MAKOTO Nihira
• 金额: $ 2.11万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16590547/
• 关键词: ethanol; ethyl glucuronide; methamphetamine; simultaneous administration; postmortem; metabolism of methamphetamine; glucuronate conjugation; rat; メタンアンフェタミン代謝物

A part of ethanol becomes ethyl glucuronide in response to glucuronate conjugation. It is said that ethyl glucuronide which can be detected at a long period of time rather than ethanol is detected, is effective in the proof of drinking. On the other hand, a psycho-stimulant is called third following abuse term, and abuse of the younger age group poses a problem. Methamphetamine is melted to alcohol.Then, methamphetamine is administered intraperitoneally with the dose of 5mg/kg to the rats and ethanol was administered orally to the rat with the dose of 4g/kg and methamphetamine and ethanol simultaneously to the rats, and the influence on the metabolism to ethanol and methamphetamine metabolism was considered this time. After administration of ethanol, methamphetamine, ethanol and methamphetamine simultaneous administration, rats were left from the 1st to the 7th in 20℃ incubator and ethanol, ethyl glucuronide, methamphetamine, and metabolites were measured.Ethanol, both in an ethanol ad … More ministration group, and a methamphetamine simultaneous administration group was not detected from serum and urine after 24 hours. Ethyl glucuronide was detected from serum and urine at 24hours after administration of ethanol and methamphetamine simultaneous administration. This result shows that measurement of ethyl glucuronide is effective in the proof of drinking. The concentration of ethyl glucronide in liver, kidney and brain was not influenced by methamphetamine simultaneous administration. On the other hand, the metabolizm of methamphetamine was influenced by ethanol simultaneous administration. Especially, the generation of p-hydroxy metabolites was reduced by ethanol simultaneous administration.Ethanol was detected from liver, kidney and brain at 7days after postmortem. Ethanol at 7 days after postmortem was detected approximately as much as that at 1day. There was no difference between the concentration of ethyl glucronide in liver, kidney and brain of ethanol group and that of methamphetamine simultaneous administration group. Less

乙醇的一部分变成乙基糖醛酸乙酯，以响应谷氨酸酯结合。据说可以在很长一段时间而不是乙醇中检测到的乙基糖苷有效地饮用。另一方面，在虐待任期后，一种心理刺激剂被称为第三，对年龄段的虐待提出了一个问题。甲基苯丙胺融化为酒精。然后，将甲基苯丙胺用5mg/kg的剂量对大鼠和乙醇进行腹膜内施用，并以4g/kg的剂量和甲基苯丙胺和乙醇同时向大鼠口服给大鼠服用，并对大鼠，对乙醇和甲基甲基苯甲酸盐含量的含量对乙醇和甲基甲醇的影响。在服用乙醇，甲基苯丙胺，乙醇和甲基苯丙胺简单施用之后，将大鼠从20至20 c孵化器和乙醇，乙醇，甲基苯丙胺，甲基苯丙胺和代谢产物的乙醇中的乙醇中的甲醇属于乙醇属性，并在乙醇中，将大鼠在20位孵化器和乙醇中排名第七，并在乙醇中进行了甲醇。和24小时后的尿液。乙醇和甲基苯丙胺同时给药后24小时从血清和尿液中检测到乙基糖苷。该结果表明，乙基糖苷的测量可有效饮用证明。肝，肾脏和大脑中乙基糖醛酸的浓度不受甲基苯丙胺同时给药的影响。另一方面，甲基苯丙胺的代谢受到乙醇同时给药的影响。尤其是，乙醇同时给药减少了P-羟基代谢产物的产生。在验尸后7天，从肝脏，肾脏和脑中检测到乙醇。验尸后7天，在1天的时间内检测到乙醇。乙醇组的肝脏，肾脏和大脑的乙基谷替尼与甲基苯丙胺同时给药组的浓度没有差异。较少的