Development of biodegradable polymers that can recognize microorganisms

开发可识别微生物的生物可降解聚合物

基本信息

批准号：
16510068
负责人：
OSAWA Satoshi
金额：
$ 1.6万
依托单位：
Kanazawa Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

The goal on this research is to prepare biodegradable polymer that have ability of recognition for microorganisms. For the purpose, we have prepared various microscopic patterns with different size on the surface of biodegradable polymers. It was fond that the polymer surface recognized fungi by controlling the micro-scale size of porous structure and regularly aligned concavity and convexity structures.Smooth biodegradable polymer surface did not adsorb any type of fungi. On the other hand, fungi was strongly adsorbed to the concavity and convexity structure with the cross pitch of 30μm x 30μm. Producing the water repellent surface onto biodegradable polymer must result in some new functions. The antibacterial property may also be obtained by the water repellency on the biodegradable polymer surface. Among water repellent natural leaves, we have chosen a structure of aroid leaf for preparing super-hydrophobic surface on biodegradable sheet since it has high water contact angle and the concavity-pattern is thought to be enough handle for a material use. Transcribing aroid structure gave 30μm ordered concavity-pattern on biodegradable polymer surface and the solvent treatment resulted in sub-micrometer ordered roughness.The water repellent natural leaves usually have antibacterial property due to the prevention of water. To investigate the antibacterial property, the transcribed biodegradable samples were soaked into fungus culture having isolated Asperugillus sp and E.coli. The filamentous fungus and bacteria did not grow on the transcribed surface with solvent treatment. The results suggested that combination of two ordered structures, i.e. several micrometer and sub-micrometer patterns recognize microorganisms.

这项研究的目的是准备具有微生物识别能力的可生物降解聚合物。为此，我们准备了各种显微镜图案，在可生物降解聚合物表面上具有不同的大小。很喜欢聚合物表面通过控制多孔结构的微尺度并定期对齐凹度和凸结构来识别真菌。光滑的可生物降解聚合物表面没有吸附任何类型的真菌。另一方面，真菌被强烈吸附到30μmx30μm的横向凹槽结构上。在可生物降解的聚合物上产生驱虫表面必须产生一些新功能。也可以通过可生物降解聚合物表面的水排泄性获得抗菌特性。在防水天然叶片中，我们选择了一个芳香叶结构，用于在可生物降解板上制备超吞噬表面，因为它具有很高的水接触角，并且凹面模式被认为足以用于物质使用。转录的AROID结构在可生物降解的聚合物表面上有30μm有序的凹面模式，并且溶液处理导致了亚微米的序列，驱虫剂的自然叶通常由于预防水而具有抗菌特性。为了研究抗菌特性，将转录的可生物降解样品浸入具有分离的Asperugillus sp和e.coli的真菌培养物中。丝状真菌和细菌没有通过溶液处理在转录的表面上生长。结果表明，两个有序结构的组合，即识别的微生物，几微米和亚微米模式。