Effects of physical stimulations on regeneration of peripheral nerves and denervated muscle fibers

物理刺激对周围神经和失神经肌纤维再生的影响

基本信息

批准号：
16500342
负责人：
MIKI Akinori
金额：
$ 2.24万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

Effects of physical stimulations (electromagnetic stimulation, electric stimulation, ultrasound stimulation, stretch) on nerve and muscle regeneration and wound healing were morphologically and immunohistochemically investigated1.Effects of physical stimulation on wound healing were morphologically studied in the injured mouse skin. Our findings suggest that ultrasound stimulation and electromagnetic stimulation promote the wound healing, but leaser irradiation was not effective.2.When the stretch was applied soon after the eccentric exercise, muscle swelling and secondary degeneration at the injury site were lightened and muscle regeneration was promoted It has been said that one of the reasons for delayed onset muscle soreness (DOMS) might be the swelling of muscles occurring one or two days after the extensive exercise. The findings of the present study suggest that adequate stretch soon after the exercise might be useful to reduce the DOMS.3.It has been widely accepted that electrical and electromagnetic stimulation promotes peripheral nerve regeneration, and also that macrophages and Schwann cells play important role for nerve regeneration. In the present study, influence of electromagnetic stimulation on expression of nerve growth factor (NGF) in the injured sciatic nerve was immunohistochemically investigated. When the electromagnetic stimulation was applied one day after the injury, expression of NGF at the injury site increased. Electron microscopically, immunoreaction for NGF was detected in the cytoplasm of Schwann cell and fibroblasts and along the basal lamina of Schwann cells.

从形态学和免疫组织化学角度研究物理刺激（电磁刺激、电刺激、超声刺激、牵拉）对神经肌肉再生和伤口愈合的影响1。以受伤小鼠皮肤为形态学研究物理刺激对伤口愈合的影响。我们的研究结果表明，超声刺激和电磁刺激促进伤口愈合，但激光照射效果不佳。2.离心运动后立即进行拉伸，可以减轻损伤部位的肌肉肿胀和继发性变性，促进肌肉再生。据说延迟性肌肉酸痛（DOMS）的原因之一可能是剧烈运动后一两天出现肌肉肿胀。本研究的结果表明，运动后立即进行充分的伸展运动可能有助于减少 DOMS。 3. 人们普遍认为，电和电磁刺激可促进周围神经再生，巨噬细胞和雪旺细胞在神经再生中发挥着重要作用。神经再生。在本研究中，通过免疫组织化学研究了电磁刺激对受伤坐骨神经中神经生长因子（NGF）表达的影响。当损伤一天后施加电磁刺激时，损伤部位的 NGF 表达增加。电镜下，在施万细胞和成纤维细胞的细胞质中以及沿着施万细胞的基底层检测到NGF的免疫反应。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

皮膚組織修復における物理療法の有効性

物理疗法在皮肤组织修复中的有效性

DOI：
发表时间：
2004
期刊：
理学療法 21巻11号
影响因子：
0
作者：
Shinohara H;Ogata A;Miki A;篠原英記
通讯作者：
篠原英記

Repairing process in the transected muscle fibers of the mouse tibialis anterior.

小鼠胫骨前肌横切肌纤维的修复过程。

DOI：
发表时间：
2006
期刊：
JJPTA 9(印刷中)
影响因子：
0
作者：
T.Saito;N.Suzuki;A.Hattori;S.Suzuki;M.Hayashibe;Y.Otake;A.Uchiyama;Yamamoto D;Tasaki H;Fujita N;松原貴子;松原貴子;藤田直人;藤本太郎;大鶴直史;Matsumoto M
通讯作者：
Matsumoto M

Effects of stretch on muscle regeneration in the damaged mouse soleus muscle after eccentric exercise.

拉伸对偏心运动后受损小鼠比目鱼肌再生的影响。

DOI：
发表时间：
2005
期刊：
Bull Allied Med Sci Kobe 22(印刷中)
影响因子：
0
作者：
T.Saito;N.Suzuki;A.Hattori;S.Suzuki;M.Hayashibe;Y.Otake;A.Uchiyama;Yamamoto D;Tasaki H;Fujita N;松原貴子;松原貴子;藤田直人;藤本太郎;大鶴直史;Matsumoto M;Tasaki H;田崎洋光;村上恵津子;Matsumoto M;Matsubara T
通讯作者：
Matsubara T

Effects of physical stimulation on wound healing in the injured mouse skin (in Japanese)

物理刺激对小鼠受伤皮肤伤口愈合的影响（日语）