Electrophysiologic and Histologic Study of Blue Cone in Rabbit Retina

兔视网膜蓝锥体的电生理和组织学研究

• 批准号: 14571689
• 负责人: YAMAMOTO Shuichi
• 金额: $ 2.05万
• 依托单位: Chiba University (2003)Toho University (2002)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571689/
• 关键词: Blue cone electroretinogram; LED built-in contact lens electrode; X-linked retinoschisis; Multiple evanescent white dot syndrome; Rabbit eye; 網膜電図; 青錐体; LED電極

1)To examine the blue cone electroretinogram, we developed the blue LED built-in contact lens electrode.2)Responses from the blue cone were clearly and repeatedly recorded from normal human eyes using this new electrode.3)Temporal frequency characteristics obtained from the electroretinogram was quite similar those reported in previous psychophysical studies.4)Smaller contact lenses were developed for rabbit eyes, and the blue cone electroretinograms were successfully recorded.5)Electroretinograms were examined in patients with various retinal diseases, such as X-linked retinoschisis and multiple evanescent white dot syndrome, to study retinal function, in order to compare with those m experimental animals.

1) 为了检查蓝锥体视网膜电图，我们开发了蓝色 LED 内置隐形眼镜电极。2) 使用这种新电极，可以清晰、重复地记录正常人眼的蓝锥体响应。3) 从蓝锥体获得的时间频率特性视网膜电图与之前心理物理学研究中报道的非常相似。4）为兔眼开发了更小的隐形眼镜，并成功记录了蓝锥体视网膜电图。5）对患有各种视网膜疾病的患者进行了视网膜电图检查，例如X连锁视网膜劈裂症和多发性消失白点综合征，来研究视网膜功能，以便与那些实验动物进行比较。

项目成果

Mitamura Y, Yamamoto S, et al.: "Monocyte chemotactic protein-1 level in the vitreous of patients with proliferative vitreoretinopathy"Jpn J Ophthalmol. 46. 218-221 (2002)

Mitamura Y、Yamamoto S 等人：“增殖性玻璃体视网膜病变患者玻璃体中的单核细胞趋化蛋白 1 水平”Jpn J Ophthalmol。

Uemoto R, Yamamoto S, Aoki T, Tsukahara I, Yamamoto T, Takeuchi S.: "Macular configuration determined by optical coherence tomography after idiopathic macular hole surgery with or without internal limiting membrane peeling."Br J Ophthalmol. 86. 1240-1242

Uemoto R、Yamamoto S、Aoki T、Tsukahara I、Yamamoto T、Takeuchi S.：“在有或没有内界膜剥离的特发性黄斑裂孔手术后通过光学相干断层扫描确定黄斑结构。”Br J Ophamol。

Yamamoto T, Hitani K, Tsukahara I, Yamamoto S, Kawasaki R, Yamashita H, Takeuchi S.: "Early postoperative retinal thickness changes and complications after vitrectomy for diabetic macular edema."Am J Ophthalmol. 135. 14-19 (2003)

Yamamoto T、Hitani K、Tsukahara I、Yamamoto S、Kawasaki R、Yamashita H、Takeuchi S.：“糖尿病黄斑水肿玻璃体切除术后早期视网膜厚度变化和并发症。”Am J Ophthalmol。

Mitamura Y, Takeuchi S, Yamamoto S, Yamamoto T, Tsukahara I, Matsuda A, Tagawa Y, Mizue Y, Nishihara J.: "Monocyte chemotactic protein-1 level in the vitreous of patients with proliferative vitreoretinopathy."Jpn J Ophthalmol. 46. 218-221 (2002)

Mitamura Y、Takeuchi S、Yamamoto S、Yamamoto T、Tsukahara I、Matsuda A、Takawa Y、Mizue Y、Nishihara J.：“增殖性玻璃体视网膜病变患者玻璃体中的单核细胞趋化蛋白-1 水平。”Jpn J Ophthalmol。

Uemoto R, Yamamoto S, Takeuchi S: "Epimacular proliferative response following internal limiting membrane peeling for idiopathic macular holes"Graefe.Arch.Clin.Exp.Ophthalmol.. 242. 177-180 (2004)

Uemoto R、Yamamoto S、Takeuchi S：“特发性黄斑裂孔内界膜剥离后黄斑外增殖反应”Graefe.Arch.Clin.Exp.O善眼科.. 242. 177-180 (2004)