The association of polymorphism in dioxin related genes with leiomyoma and endometriosis

二恶英相关基因多态性与子宫肌瘤、子宫内膜异位症的关系

• 批准号: 14571582
• 负责人: ASADA Hironori
• 金额: $ 1.79万
• 依托单位: KEIO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571582/
• 关键词: dioxin; leiomyoma; endometriosis

Estrogen dependence and immune modulations are established features of endometriosis, and environmental contaminants have been suggested to play a role in the pathobiology of endometriosis. Previous work in nonhuman primates has shown that exposure to the dioxin 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with an increased prevalence and severity of endometriosis. The effects of dioxins are mediated via the arylhydrocarbon receptor(AHR), aryl hydrocarbon receptor nuclear receptor nuclear translocator(ARNT), and aryl hydrocarbon receptor repressor(AHRR).We identified and characterized the human homolog of mouse AHRR, taking advantage of the publicly available draft version of the human genome sequence. After detecting the AHRR polymorphism, the genetic polymorphism of AHR, ARNT were also investigated. We explored the association of the AHR, ARNT, and AHRR polymorphism with endometriosis in a case-control study. Although no significant correlation was found between endometriosis and polymorphism of AHR, ARNT, or AHRR genes, pathological phenotypes of endometriosis may be associated with the dioxin related genes other than AHR, ARNT, and AHRR.

雌激素依赖性和免疫调节是子宫内膜异位症的建立特征，并且已经提出环境污染物在子宫内膜异位症病理生物学中发挥作用。非人类灵长类动物的先前工作表明，暴露于二恶英2,3,7,8-四氯迪本佐-P-二恶英（TCDD）与子宫内膜异位症的患病率和严重程度的增加有关。二恶英的作用是通过芳基水合碳受体（AHR），芳烃受体核受体核受体核转运剂（ARNT）和芳基烃受体阻遏物（AHRR）介导的。在检测AHRR多态性后，还研究了ARNT的遗传多态性。在一项病例对照研究中，我们探讨了AHR，ARNT和AHRR多态性与子宫内膜异位症的关联。尽管在AHR，ARNT或AHRR基因的子宫内膜异位症与多态性之间没有明显的相关性，但子宫内膜异位症的病理表型可能与AHR，ARNT和AHRR以外的其他相关基因有关。

项目成果

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Tei C、Maruyama T、Kuji N、Miyazaki T、Mikami M、Yoshimura Y：“反复 IVF-ET 失败的不明原因不孕患者子宫内膜中 avb3 整合素的表达降低：达那唑治疗的改善。”J Assist Reprod Genet..

Minegishi K, Tanaka M, Nishimura O, Tanigaki S, Miyakoshi K, Ishimoto H, Yoshimura Y: "Reactive oxygen species mediate leukocyte-endotheclium interactions in prostaglandin F 2a-induced luteolysis in rats."Am J Physiol Endocrinol Metab. 283. E1308-E1315 (2

Minegishi K、Tanaka M、Nishimura O、Tanigaki S、Miyakoshi K、Ishimoto H、Yoshimura Y：“活性氧在前列腺素 F 2a 诱导的大鼠黄体溶解中介导白细胞-内皮相互作用。”Am J Physiol Endocrinol Metab。

Kosaki K, Suzuki T, Muroya K, Hasegawa T, Sato S, Matsuo N, Kosaki R, Nagai T, Hasegawa Y, Ogata T: "PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome."J Clin Endocrinol Metab. 87(8). 3529

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吉村泰典主编：《子宫内膜异位症知情同意书系列》 Iyaku Journal Co., Ltd. 44 (2002)

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