Involvement of COX-2 and free radical-related enzymes in the malignant transformation of ovarian endometrial cyst

COX-2及自由基相关酶参与卵巢子宫内膜囊肿恶变

• 批准号: 14571534
• 负责人: TANAKA Hidenori
• 金额: $ 2.56万
• 依托单位: Akita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571534/
• 关键词: free radical; chocolate cyst; ovarian carcinoma; endometrial adenocarcinoma; COX-2; SOD; eNOS; carcinogenesis; 子宮内膜症; 卵巣チョコレート嚢胞; シクロオキシゲナーゼ

◇Immunohistochemical expression of superoxide dismutase in endometrial adenocarcinomaThis study examined : (1)the distribution of Cu/Zn-SOD expression in endometrial adenocarcinomas ; (2)differences in this expression based on histological type ; and (3)variations in patient survival rate with intensity of expression.Stronger expression of Cu/Zn-SOD was observed in endometrial carcinomas, particularly in clear cell adenocarcinoma, when compared to normal endometrium. This suggests that Cu/Zn-SOD expression might be correlated with initial carcinogenetic factor of the endometrial adenocarcinoma.◇Involvement of Cyclooxygenase-2 in Ovarian Chocolate Cyst and Ovarian Cancerthe expression in ovarian chocolate cyst revealed significantly higher than that of the control. Among the groups of ovarian carcinoma, the highest staining was found in endometrioid type, followed by clear cell type and serous type. In the majority of ovarian chocolate cyst and ovarian cancer cases, COX-2 was diffusely and granularly stained in cytoplasm. No difference in the localization of COX-2 staining was seen between the basement membrane and the lumen of glands. In conclusion, overexpression of COX-2 may be intricately involved in malignant transformation of ovarian chocolate cysts.

◇子宫内膜腺癌研究中的超氧化物的免疫组织化学表达研究：（1）基于此表达的cu/Zn-sod ression在子宫内膜腺癌中的分布；在子宫内膜的子宫内膜癌中观察到Cu/Zn-SOD。在卵巢癌中，在子宫内膜类型类型中发现了最高的染色，其次是透明细胞类型，大多数卵巢囊肿和卵巢癌Casses中的染色。在膜上看到COX-2染色的定位和腺体的腔内，COX-2的过表达可能与卵巢巧克力囊肿的恶性转化有关。

项目成果

Tanaka H, Sato H, Sato N, Takahashi O, Ota H, Hirano H, Tanaka T.: "Adding HPV16 testing to abnormal cervical smear is useful for predicting CIN3-A prospective study."Acta Obstet Gynecol Scand. 83. 497-500 (2004)

Tanaka H、Sato H、Sato N、Takahashi O、Ota H、Hirano H、Tanaka T.：“在异常宫颈涂片中添加 HPV16 检测对于预测 CIN3-A 前瞻性研究非常有用。”Acta Obstet Gynecol Scand。

Ota H, Tanaka H, Takahashi O, Igarashi S, Tanaka T.: "Enzymes related to oxidative stress in ovarian endometrial cyst and ovarian carcinoma"Endometriosis Kenkyukaishi. 24. 157-161 (2003)

Ota H、Tanaka H、Takahashi O、Igarashi S、Tanaka T.：“与卵巢子宫内膜囊肿和卵巢癌氧化应激相关的酶”子宫内膜异位症研究会。

Tanaka H, Sato H, Sato N, Takahashi O, Ota H, Hiran H, Tanaka T.: "Adding HPV16 testing to abnormal cervical smear is useful for predicting CIN3-A prospective study"Acta Obstet Gynecol Scand. (in press). (2004)

Tanaka H、Sato H、Sato N、Takahashi O、Ota H、Hiran H、Tanaka T.：“在异常宫颈涂片中添加 HPV16 检测有助于预测 CIN3-A 前瞻性研究”Acta Obstet Gynecol Scand。

Tanaka H, Ota H, Sato H, Sato N, Takahashi O, Tanaka T.: "Immunohistochemical expression of superoxide dismutase in endometrial adenocarcinoma"Shikyukinsoubyouhenkenkyukaishi. 3. 8-9 (2003)

Tanaka H、Ota H、Sato H、Sato N、Takahashi O、Tanaka T.：“子宫内膜腺癌中超氧化物歧化酶的免疫组织化学表达”Shikyukinsoubyouhenkenkyukaishi。

田中秀則, 太田博孝, 佐藤宏和, 佐藤直樹, 高橋 道, 田中俊誠: "子宮体癌における銅亜鉛スーパーオキシド消去酵素(Cu/Zn-SOD)の発現"子宮筋層病変生検研究会誌. 3. 8-9 (2003)

Hidenori Tanaka、Hirotaka Ota、Hirokazu Sato、Naoki Sato、Michi Takahashi、Toshinori Tanaka：“子宫内膜癌中铜锌超氧化物清除酶 (Cu/Zn-SOD) 的表达”子宫肌层病变活检研究组杂志 3 .8-。 9 (2003)