Regulation o the Hypothalanmo-Pituitary-Gonadal Function by Appetite-Regulating Factors

食欲调节因子对下丘脑-垂体-性腺功能的调节

• 批准号: 14571071
• 负责人: WATANOBE Hajime
• 金额: $ 1.98万
• 依托单位: International University of Health and Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571071/
• 关键词: Appetite-regulating factors; Endocrine function; Leptin; Prolactin; α-MSH; Cytokine; Growth hormone; Melanocortin; 雌雄差; メラノコルチン-4受容体; 国際情報交換; スウェーデン:イタリア; 性腺機能; LH; GT1-7細胞; GnRH; 受容体

Leptin is an adipocyte-derived hormone serving as an appetite-regulating factor, and furthermore regulates various neuroendocrine functions linking nutrition and endocrine systems. The present research project led to the following novel, data.1.Mechanism underlying the. sex-related difference in plasma leptin concentrations. It is well known that females have higher leptin levels than males in humans and also other mammals, but its underlying mechanism remains elucidated. The present study suggests that the neonatal exposure to androgens in male rats mediates, at least in part, the male-type lower leptin concentrations.2.Mechanism of leptin-induced prolactin secretion. This subject was examined in the present study, and the. following data were obtained. Stimulation of prolactin secretion by leptin is mediated by none of dopamine, serotonin, vasoactive intestinal peptide, prolactin-releasing peptide, or beta-endorphin, and only alpha-melanocyte-stimulating hormone seems to play a signi … More ficant intermediary role by way of the melanocortin 4 receptor in the brain.3.Mechanism of the suppression of the hypothalamo-pituitary-gonadal axis by inflammatory cytokines. It is well established that endotoxemia in bacterial infections induces the suppression of the hypothalamo-pituitary-gonadal axis, but the details of cytokines' roles in this phenomenon are not fully understood. The present study demonstrates that interleukin-1beta and tumor necrosis factor-alpha are almost equipotent in suppressing the release of gonadotropin-releasing hormone from rat hypothalamus, but the involvement of interleukin-6 is insignificant in this regard.4.Role of melanocortin receptors in leptin-induced growth hormone secretion. It has been reported that the melanocortin 4 receptor in the brain mediates the actions of leptin on the hypothalamo-pituitary-thyroid/gonadal/adrenal axes. This study demonstrated that leptin-induced stimulation of growth hormone release is not mediated by either the melanocortin 3 or 4 receptor. Less

瘦素是一种脂肪细胞衍生的马酮，可作为食欲调节因子，并调节连接营养和内分泌系统的各种神经内分泌功能。当前的研究项目导致了以下小说。血浆瘦素浓度与性别相关的差异。众所周知，女性在人类和其他哺乳动物中的瘦素水平高于雄性，但其潜在机制仍被阐明。本研究表明，雄性大鼠中的新生儿暴露于雄激素介导，至少部分是雄性型瘦素浓度。2。瘦素诱导的催乳素分泌的机制。在本研究中检查了该主题。获得以下数据。瘦素对催乳素分泌的刺激没有由多巴胺，5-羟色胺，血管活性肠肽，催乳素释放肽或β-内啡肽以及α-甲状腺细胞刺激性刺激的马酮的作用，似乎只能通过signi的含量来构成Indmediary Introlin insimient of Meranimin insiminty 4通过炎症细胞因子的下丘脑 - 垂体 - 基达轴。众所周知，细菌感染中的内毒素血症会诱导下丘脑 - 垂体 - 基达轴的抑制，但是细胞因子在这种现象中的作用的细节尚未完全了解。本研究表明，白介素-1beta和肿瘤坏死因子-Alpha几乎有计划地抑制大鼠下丘脑释放促性腺激素释放的马酮，但肠介菌-6的参与在这方面是微不足道的。据报道，大脑中的黑色素皮质4受体介导瘦素对下丘脑 - 垂体 - 甲状腺/性腺/性腺/肾上腺轴的作用。这项研究表明，瘦素诱导的生长马释放的刺激并未由黑色皮质素3或4受体介导。较少的

项目成果

Watanobe H: "Manipulation of neonatal gonadal steroid milieu and leptin secretion in later life in male and female rats"Regulatory Peptides. 110. 219-224 (2003)

Watanobe H：“雄性和雌性大鼠新生性腺类固醇环境和晚年瘦素分泌的操纵”调节肽。

Watanobe H, Habu S: "Adrenal glucocorticoids do not mediate impaired reproductive function induced by lipopolysaccharide in rats."Neuroendocrinology. 78. 23-28 (2003)

Watanobe H、Habu S：“肾上腺糖皮质激素不会介导脂多糖诱导的大鼠生殖功能受损。”神经内分泌学。

Watanabe, H.: "Leptin regulates growth hormone-releasing factor, Somatostatin and α-melanocyte-stimulating hormone but not neuropeptide Y release in rat hypothalamus in vivo : Relation with growth hormone secretion"Journal of Neuroscience. 22・14. 6265-627

Watanabe, H.：“瘦素调节大鼠下丘脑体内生长激素释放因子、生长抑素和 α-黑素细胞刺激激素的释放，但不调节神经肽 Y 的释放：与生长激素分泌的关系”《神经科学杂志》22・14。

Watanobe H: "Leptin Regulates Growth Hormone-Releasing Factor, Somatostatin, and α-Melanocyte-Stimulating Hormone But Not Neuropeptide Y Release in Rat Hypothalamus In Vivo : Relation with Growth Hormone Secretion"Journal of Neuroscience. 22. 6265-6271 (2

Watanobe H：“瘦素调节大鼠下丘脑体内生长激素释放因子、生长抑素和 α-黑素细胞刺激激素，但不调节神经肽 Y 释放：与生长激素分泌的关系”神经科学杂志 22. 6265-6271 (2)

Watanobe H, Schioth HB: "Postnatal profile of plasma leptin concentrations in male and female rats : Relation with the maturation of the pituitary-gonadal axis."Regul Pept. 105. 23-28 (2002)

Watanobe H、Schioth HB：“雄性和雌性大鼠血浆瘦素浓度的产后概况：与垂体-性腺轴成熟的关系。”Regul Pept。