Anticardolipin antibody and childhood epiepsy

抗心磷脂抗体与儿童癫痫

基本信息

批准号：
14570717
负责人：
HAGINOYA Kazuhiro
金额：
$ 2.05万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

项目摘要

Background : Anticardiolipin antibody (aCL) is reported to be positive in patients with antiphospholipid syndrome. However, aCL has been reported in patients with various CNS disorders. We examined the frequency of aCL in patients with various kind of epilepsy in order to clarify whether aCL is involved in the pathogenesis of childhood epilepsy. Methods : Serum samples from 175 epileptic patients and 71 non-epileptic patients were obtained after informed consent. The aCL IgG was measured using an ELISA kit purchased from MBL (Nagoya, Japan). The 175 epileptic patients included 9 with idiopathic Reneralized epilepsy (IGE), 46 with symptomatic generalized epilepsy (SGE) including 21 with West syndrome, 73 with crypiogenic or symptomatic localization-related epilepsy (C/SLE), 29 with idiopathic localization-related epilepsy, and 18 with unclassified epilepsy. Results : Although the normal range of this kit is set as below 10 U/ml in adults, we tentatively set the normal range as below 15 … More U/ml. Consequently, 24% of epileptic patients and 15% of non-epileptic patients were positive for aCL. There was no significant difference between the two groups. Among epileptic patients, SGE patients were positive significantly more often than C/SLE patients (p = 0.014, Mann-Whitney U test). When epileptic patients were divided into aCL-positive (42 patients) and aCL-negative (133 patients) groups, there were, no significant differences between the two groups in terms of sex, poly-pharmacy, antinuclear antibody, antiDNA antibody, and drugs used for treatment. However, SGE and age less than one year were significantly more frequent in the aCL-positive group (p =0.014 and <0.0001, respectively). Patients whose seizure type was epileptic spasm including West syndrome were significantly more frequent in the aCL-positive group (p = 0.0001). Conclusions : We found that aCL was present in some pediatric patients with epilepsy and other non-epileplic disorders. In all of our cases, CT and MRI showed no evidence of vascular lesions. This suggests that there is a direct cross reaction between aCL and the CNS. There was a significant relationship between aCL and those who had SGE and whose seizure type, was epileptic spasm, suggesting that aCL was involved in the pathogenesis of particular type of epilepsy including West syndrome. Less

背景：据报道，抗磷脂综合征患者的抗心磷脂抗体 (aCL) 呈阳性，然而，我们检查了各种癫痫患者中 aCL 的发生率，以明确 aCL 是否存在。方法：在知情同意后获取 175 名癫痫患者和 71 名非癫痫患者的血清样本，并使用 aCL IgG 进行检测。 ELISA 试剂盒购自 MBL（日本名古屋），其中 9 例患有特发性再生性癫痫（IGE），46 例患有症状性全身性癫痫（SGE），其中 21 例患有 West 综合征，73 例患有低温或症状性定位相关性癫痫（C）。 /SLE），29 名患有特发性定位相关性癫痫，18 名患有特发性定位相关性癫痫结果：虽然该试剂盒的成人正常范围设定为低于 10 U/ml，但我们暂时将正常范围设定为低于 15 … More U/ml，24% 的癫痫患者和 15% 的非癫痫患者进行了检查。 - 癫痫患者 aCL 阳性两组之间没有显着差异，SGE 患者的阳性率明显高于 C/SLE 患者（p = 0.014，将癫痫患者分为aCL阳性组（42例）和aCL阴性组（133例）时，两组在性别、多药治疗、抗核方面无显着差异。然而，aCL 阳性组中 SGE 和年龄小于 1 岁的患者的发生率显着更高（分别为 p = 0.014 和 <0.0001）。结论：我们发现，在我们的所有病例中，一些患有癫痫和其他非癫痫疾病的儿童患者中存在 aCL，包括 West 综合征。 MRI 显示没有血管病变的证据，这表明 aCL 和 CNS 之间存在直接交叉反应。 aCL 与患有 SGE 且癫痫发作类型为癫痫痉挛，表明 aCL 参与了包括 West 综合征在内的特定类型癫痫的发病机制。