Remodeling of the airway in the Asthmatic patients

哮喘患者气道重塑

• 批准号: 14570571
• 负责人: OKAZAWA Mitushi
• 金额: $ 1.34万
• 依托单位: Fujita Health University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570571/
• 关键词: Bronchial asthma; Airway remoderlling; Ultrasonic catheter; HRCT; Mast cell; 3D reconstruction; 咳喘息; 喉頭アレルギー; 気道過敏性; 気管支鏡; 咳喘息(CVA); 喉頭アレルギー(LA); 気道平滑筋; 気管支攣縮; 気道抵抗; ボディプレチスモグラム; 平滑筋stiffness; 気道弛緩作用; メサコリン; 気道モデリング; 超音波血管カテーテル; 気道壁構築

Project 1 : Use of ultrasonic catheter to investigate airway structureUltrasonic catheter was used for real time detection of airway wall in human. Although there was significant artifact in the image while breathing, airway narrowing was detected. Since airway was locally filled with saline, artifact could be resulted from surrounded lung air. This method could be used while patient are receiving bronchoalveolar lavage, since airway and alveolus is filled with saline.Project 2 : Use of HRCT to investigate airway narrowing during bronchoconstrictionURCT and MPR (Multi Plane Reconstruction) was used to obtain the airway cross-sectional image perpendicular to the long axis of the airway. The airway lumen was not circle, rather oval. The aspect ratio of the airway ranged approximately 0.5-0.8. After bronchoconstriction induced by methacholine inhalation did not change the aspect ratio. Using MPR will provide better understanding of the airway narrowing.Project 3 : The effect of deep inspi … More ration during induce bronchoconstrictionEffect of deep inspiration was investigated in normal volunteer and asthmatic patients. In the normal volunteers, methacholine induce bronchokonstriction was reversed after deep inspiration but not in asthmatics. This reverse effect in normal volunteers did not last 5 minutes. In the week bronchoconstriction, reverse effect of deep inspiration was effective in both normal volunteer and asthmatics. The length of reverse effect, however, did not last 5 minutes.Project 4 : Distribution of mast cell in the airway of Cough variant athsma (CVA) and Laryngeal allergy (LA)Mucosal biopsy was done at larynx, carina and membranous portion of trachea and right 2^<nd> carina. The mast cells were equally distributed in these sites and there were no significant difference. Mast cell was significantly abandon in the membranous trachea in CVA than LA.Project 5 : 3D reconstruction of bronchoconstricted airway3D reconstruction of the images obtained from induced bronchoconstriction in guinea pig was investigated. Mucosal fold was longitudinally continued in the central airway. It succeeded even at branches. In the cartilaginous airway, membranous bronchiole as the daughter branch debuted. Since the membranous bronchiole has less smooth muscle compared with main airway, the luminal area was wider than main stem. Less

项目1：使用超声导管研究气道结构导管的使用，用于对人类气道壁的实时检测。尽管在呼吸时图像中有大量的人工制品，但发现气道狭窄。由于气道在当地充满了盐水，因此可以由周围的肺部空气造成人工制品。由于气道和肺泡充满了盐水2：使用HRCT调查在Bronchoctryctictrictionurct期间的气道变窄，并且使用此方法在患者接受支气管肺泡灌洗时可以使用此方法。气道管腔不是圆圈，而是椭圆形。气道的长宽比约为0.5-0.8。通过方法溶液诱导的支气管收缩后，吸入不会改变纵横比。使用MPR可以更好地了解气道狭窄。项目3：深度Inspi的影响……在正常的志愿者和哮喘患者中研究了深度灵感的诱导支气管收缩效应的更多评分。在正常的志愿者中，在深刻的灵感之后，方法上诱导支气管收缩逆转，但在哮喘患者中没有逆转。正常志愿者的这种反向影响持续5分钟。在一周的支气管收缩中，深度灵感的反向效应在正常的志愿者和哮喘患者中都是有效的。但是，反向作用的长度并未持续5分钟。项目4：在咳嗽变体ATHSMA（CVA）和喉过敏（LA）粘膜活检中的肥大细胞分布，在喉，Carina，Carina，Carina和Membranous Postion的气管和右2^<nd> Carina上进行。肥大细胞平均分布在这些位点，没有显着差异。在CVA的膜气管中，肥大细胞显着放弃，而不是5：3D重建，研究了从豚鼠中诱导的支气管收缩获得的图像的支气管收集Airway3D重建。中央气道纵向继续粘膜褶皱。即使在分支机构也成功。在软骨气道中，随着女儿分支的调试，膜的支气管。由于与主气道相比，膜间支气管的平滑肌较少，因此腔面积比主茎荒野。较少的

项目成果

利尿剤(アセタゾラミド・フロセミド)による呼吸調節機能の変化

利尿剂（乙酰唑胺/呋塞米）引起的呼吸控制功能的改变

• 发表时间: 2004
• 期刊: Medicina 41巻7号
• 作者: 林正道;岡澤光芝
• 通讯作者: 岡澤光芝

The relationship between airway wall thickness and alveolar destruction to the air flow limitation

气道壁厚度和肺泡破坏与气流限制的关系

• 发表时间: 2004
• 期刊: Kokyuukika 6
• 作者: 橋本 修;Okazawa M.
• 通讯作者: Okazawa M.

気道壁の肥厚および肺胞の破壊と気流閉塞のかかわりは?

气道壁增厚与肺泡破坏和气流阻塞之间有何关系？

• 发表时间: 2004
• 期刊: 呼吸器科 6巻4号
• 作者: K Hiramatsu;Y Saito;A Azuma;etc.;岡澤光芝
• 通讯作者: 岡澤光芝

Remodelling of the airway in the severe athma

严重哮喘时气道的重塑

• 发表时间: 2003
• 期刊: Nihon Kokyukigakkai Zassi 41
• 作者: Okazawa M et al.

Imaizumi K, Sakakibara H, Okazawa M: "Deep Inspiration does not keep airway open after methacholine induced bronchokonstriction"Am.J.Respir, Crit.Care Med.. 167. A181 (2003)

Imaizumi K、Sakakibara H、Okazawa M：“乙酰甲胆碱诱导支气管收缩后，深吸气不能保持气道开放”Am.J.Respir、Crit.Care Med.. 167. A181 (2003)