Development of three-dimensional image programs for research and education of human embryology

开发用于人类胚胎学研究和教育的三维图像程序

• 批准号: 14570011
• 负责人: MIZUTA Shinobu
• 金额: $ 2.18万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570011/
• 关键词: Embryology; Specimen of human embryo; Database; three-dimensional image; MR Microscope; Serial section; Isosurface; Spatiotemporal model; 医学教育; 等値面構造; Contour Tree; 領域抽出; 連続切片標本; 三次元モデル; Embryology; Specimen of human embryo; Database; three-dimensional image; MR Microscope; Serial section; Isosurface; Spatiotemporal model; 医学教育; 等値面構造; Contour Tree; 領域抽出; 連続切片標本; 三次元モデル

The purpose of this research is to develop programs to assist the research and education of human embryology. In order to view the morphological change in the development of human embryos, we have acquired tree-dimensional (3D) images from specimens using equipments such as MR microscopes, extracting and displaying the 3D shapes of external and internal organs. Our results areas follows:(1)Congenital Anomaly Research Center in Kyoto University has huge number of specimens of human embryo. We have developed a system to retrieve and display the specimens efficiently, where the morphological features of the specimens can be compared from each other or with a standard 3D model, by viewing 3D images.(2)A part of the specimens described above are stored as serial sections. We have developed a system to reconstruct 3D shapes from the serially sectioned specimens, introducing the photographs of outside to improve the accuracy of reconstruction.(3)In order to assist 3D image analysis, we have developed procedures to display the topological relationship of isosurfaces in 3D scalar field, to describe the relationship in 3D digital images, and to extract regions (external and internal organs for the images of specimens) interactively using the relationship from 3D images.(4)We have developed a spaciotemporal 4D model describing not only morphological change of a human embryo, but also appearance and disappearance of internal organs. Using this model, we have developed a program to display the standard shape of external and internal organs with those of specimens extracted by procedures (3).

这项研究的目的是制定计划，以帮助人类胚胎学研究和教育。为了查看人类胚胎发展的形态变化，我们使用MR显微镜等设备从样品中获取了树木维（3D）图像，从而提取和显示外部和内脏的3D形状。我们的结果领域如下：（1）京都大学的先天性异常研究中心有大量人类胚胎标本。我们已经开发了一个系统来有效地检索和显示样品，其中可以通过查看3D图像相互比较样品的形态特征或与标准3D模型进行比较。（2）上述标本的一部分被存储为串行部分。 We have developed a system to reconstruct 3D shapes from the serially sectioned specimens, introducing the photographs of outside to improve the accuracy of reconstruction.(3)In order to assist 3D image analysis, we have developed procedures to display the topological relationship of isosurfaces in 3D scalar field, to describe the relationship in 3D digital images, and to extract regions (external and internal organs for the images of specimens) interactively using the relationship from 3D图像。（4）我们开发了一个暂时颞4D模型，它不仅描述了人类胚胎的形态变化，而且还描​​述了内部器官的外观和消失。使用此模型，我们开发了一个程序来显示外部和内部器官的标准形状，并通过程序（3）提取的标本。