Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) Cohort

新生儿表观遗传学研究 (NEST) 队列的随访和维护

• 批准号: 10443683
• 负责人: Cathrine Hoyo
• 金额: $ 38.02万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10443683
• 关键词: Aberrant DNA Methylation; Address; Adult; Age; Algorithms; Architecture; Arsenic; Biological Specimen Banks; Birth; Blood; Blood Pressure; Cadmium; Cardiometabolic Disease; Cardiovascular Diseases; Cause of Death; Chemicals; Child; Childhood; Chronic Disease; Clinic; Clinical Data; Code; Cohort Studies; Collaborations; Communities; Consent; County; Cross-Sectional Studies; DNA Methylation; Data; Data Collection; Data Linkages; Data Set; Data Sources; Databases; Developed Countries; Developing Countries; Development; Diagnosis; Discipline; Disease; Drug Prescriptions; Elderly; Embryo; Enrollment; Ensure; Environment; Environmental Exposure; Epidemiologist; Epigenetic Process; Etiology; Exposure to; Follow-Up Studies; Functional disorder; Funding; Gastroenterology; Genes; Genetic; Geography; Goals; Growth; Health system; Heavy Metals; Height; High Prevalence; Hyperglycemia; Hyperinsulinism; Hyperlipidemia; Impairment; Internet; Investigation; Knowledge; Lead; Life; Life Cycle Stages; Link; Longterm Follow-up; Low Birth Weight Infant; Maintenance; Malignant Neoplasms; Medicaid; Medical Records; Meta-Analysis; Metabolic; Metabolic Diseases; Methylation; Newborn Infant; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; Obesity; Obesity associated cancer; Online Systems; Onset of illness; Outcome; Paper; Participant; Pediatrics; Perinatology; Persons; Policies; Predisposition; Pregnant Women; Prevalence; Procedures; Process; Prospective cohort; Protocols documentation; Psychology; Puberty; Quality Control; Questionnaires; Reporting; Research; Resources; Retrospective Studies; Retrospective cohort study; Running; Soil; Specimen; Standardization; Testing; Time; Toxicology; Training; Weight; Woman; aged; blood lead; cardiometabolism; cardiovascular risk factor; cigarette smoking; cohort; data repository; data reuse; data sharing; design; early life exposure; environmental chemistry; epidemiologic data; epigenome; epigenomics; folic acid supplementation; follow-up; human subject protection; imprint; improved; in utero; lead exposure; maternal obesity; neurodevelopment; neurodevelopmental effect; novel; nutrition; offspring; pollutant; prenatal; prenatal exposure; preservation; programs; public health intervention; quality assurance; recruit; sample collection; searchable database; skills; stem; stressor; superfund site; usability

Project Summary Non-communicable diseases including cardiovascular diseases, metabolic diseases and cancer are the leading causes of death in developed countries. These diseases are predicted to also be the leading causes of death in developing countries by 2020. Stemming the increase in the prevalence of these diseases will require a more detailed understanding of their etiology using a life course approach. Existing data linking early chemical and non-chemical stressors to these adult-onset diseases derives either from well-powered cross- section or retrospective cohort studies, or under-powered prospective cohorts with short follow-up. Epigenetic alterations—a mechanism by which genes respond to the environment—have been hypothesized to link observed associations between early stressors and multiple common diseases. However, prior cross-sectional and retrospective studies have lacked early life covariate data and specimens that would help to examine the links between early life stressors and later life disease. To address these knowledge gaps, in 2005-2011, we developed the pre-birth Newborn Epigenetics STudy (NEST) cohort comprising more than 2000 women, and followed their offspring until age 3-5 years. The NEST cohort has become a resource used by our group to identify novel associations between chemical and non-chemical stressors, and early signs of these non- communicable diseases, including cardiometabolic dysfunction. This resource has also been used to replicate novel findings by other groups, to pool with other cohorts to enhance statistical power, and to test new hypotheses by others. Our overarching goal for this application is to maintain this resource. This will be accomplished through the retention of trained staff with the critical skills to, (i) maintain and enrich the cohort by collecting additional data and specimens, (ii) develop and implement quality control and quality assurance protocols on existing and to-be-collected data and specimens, and, (iii) establish a comprehensive web-based database to increase our capability for data re-use and pooling with other cohorts to enhance statistical power. Direct web access will also simplify the process of data sharing with other birth cohorts and prepare our data for linkage. We will follow the cohort until age 11-17 years. This age range coincides with peri-puberty and puberty—developmental windows of heightened susceptibility to the non-communicable diseases under investigation. We also will link NEST data with identifiable Health System- and State-run medical records. Completing the proposed study will result in an enriched specimen repository with quality control and quality assurance, and annotated epidemiologic and clinical data. These data and specimens will facilitate rapid hypothesis testing by our group as well as data sharing and linkage with other cohorts to enhance statistical power. Data contributing to our understanding of the developmental origins of adult-onset non-communicable diseases are critical for guiding public health intervention efforts.

项目概要 非传染性疾病包括心血管疾病、代谢性疾病和癌症等 预计这些疾病也是发达国家死亡的主要原因。 到 2020 年，发展中国家的死亡人数将增加。要阻止这些疾病的流行率上升，需要 使用生命历程方法更详细地了解其病因。 这些成人发病疾病的化学和非化学应激源要么来自强大的交叉 切片或回顾性队列研究，或短期随访的动力不足的前瞻性队列。 改变——基因对环境做出反应的一种机制——已被用来将 然而，观察到早期压力源与多种常见疾病之间的关联。 回顾性研究缺乏早期生命的协变量数据和样本来帮助检查 为了解决这些知识差距，我们在 2005 年至 2011 年期间研究了早期生活压力源与晚年疾病之间的联系。 开发了由 2000 多名女性组成的产前新生儿表观遗传学研究 (NEST) 队列，以及 跟踪他们的后代直到 3-5 岁，NEST 队列已成为我们小组使用的资源。 确定化学和非化学应激源之间的新关联，以及这些非化学应激源的早期迹象 该资源也被用来复制传染病，包括心脏代谢功能障碍。 其他群体的新发现，与其他群体汇集以增强统计能力，并测试新的 其他人的假设。我们此应用程序的首要目标是维护此资源。 通过保留具有关键技能的训练有素的工作人员来实现：(i) 维持和充实队伍 通过收集额外的数据和样本，（ii）制定并实施质量控制和质量保证 关于现有和将要收集的数据和样本的协议，以及 (iii) 建立一个全面的基于网络的 数据库，以提高我们的数据重用能力以及与其他群体的汇集能力，以增强统计能力。 直接网络访问还将简化与其他出生队列共享数据并准备我们的数据的过程 我们将跟踪该队列直至 11 至 17 岁。 青春期——胃肠道对非传染性疾病易感性的发育窗口 我们还将 NEST 数据与可识别的卫生系统和国家运行的医疗记录联系起来。 完成拟议的研究将产生一个具有质量控制和质量的丰富样本库 这些数据和样本将有助于快速确定和注释流行病学和临床数据。 我们小组的假设检验以及数据共享和与其他群体的联系以增强统计 数据有助于我们了解成人发病的非传染性疾病的发育起源。 疾病对于指导公共卫生干预工作至关重要。

项目成果

A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth.

• DOI: 10.1073/pnas.2212178119
• 发表时间: 2022-11-08
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

A Cross-Sectional Cohort Study of the Effects of FGF23 Deficiency and Hyperphosphatemia on Dental Structures in Hyperphosphatemic Familial Tumoral Calcinosis.

• DOI: 10.1002/jbm4.10470
• 发表时间: 2021-05
• 期刊: JBMR plus
• 影响因子: 3.8
• 作者: Lee AE;Chu EY;Gardner PJ;Duverger O;Saikali A;Wang SK;Gafni RI;Hartley IR;Ten Hagen KG;Somerman MJ;Collins MT
• 通讯作者: Collins MT