Visualization of Molecular Mechanism of Brain Function and Neurological Disease Using High Magnetic Field MRI

使用高磁场 MRI 可视化脑功能和神经系统疾病的分子机制

基本信息

批准号：
17591275
负责人：
HARADA Masafumi
金额：
$ 2.5万
依托单位：
The University of Tokushima
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591275/
关键词：
MRS GABA NAA MEGA-PRESS SPECT 3T MRI Glutamate neurotrasmitter MR spectroscopy

项目摘要

Gamma-aminobutyric acid (GABA) in normal subjects and patients was measured using MEGA-PRESS on clinical 3T MR apparatus and the GABAnergic index was proposed. The result of GABA nergic index was compared with the data of receptor scintigraphy in the autistic patients.Ten autistic patients (2〜11 y.o., mean 5.2 y.o.) were measured by routine anatomical MRI and after obtaining informed consents from their parents, single voxel proton MRS including MEGA-PRESS was conducted. As age-matched normal controls, six children (3〜12 y.o., mean 6.6 y.o.) who show no neurological abnormality and anatomical disorder in the brain by MRI were recruited after getting informed consents. The measured locations were left frontal lobe and left basal ganglia. The in-vitro data of NAA, Glutamine, Glutamate and GABA were acquired by MEGA-PRESS and set as a basis-set for LCModel. The quantification of signals in the difference and original spectrum by MEGA-PRESS were conducted by LCModel. A new parameter for GABAnergic neurons was defined as followed: GABAnergic index=(GABA signal from a subtracted spectra divided by NAA signal from the original spectra without selective pulses).The result of GABAnergic index in the frontal lobe and basal ganglia and this index in the frontal lobe on autistic patients were lower than that on normal controls (p<0.05). However, there is no difference in the basal ganglia between autism and normal controls. An example of the receptor scintigraphy (iomazenil SPECT) showed the activity ratio of the frontal lobe/cerebellum in autism was lower than that of the normal controls. This finding on the receptor scintigraphy was almost consistent with the result of GABAnergic index, suggesting the decrease of GABAnergic activity in the frontal lobe on autistic patients.The GABAnergic index calculated from MEGA-PRESS data would be useful for the evaluation of neurochemical disorder on autistic patients.

在临床3T MR设备上测量了正常受试者中的γ-氨基丁酸（GABA），并将GABA Nergic指数的结果与自闭症患者的受体闪烁体进行了比较（自闭症患者）。 2-11 Y.O.，平均5.2 Y.O.）通过常规的解剖学MRI和从其parents获得知情的销售后，包括大量的正常对照，六个孩子（3〜12 Y.O.） 6.6 y.对于LCMODEL对照（p <0.05）在自闭症患者的额叶中，从巨型 - 压力数据中钙化的gabanerms对自闭症患者的效果障碍很有用。

项目成果

期刊论文数量（13）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

MR spectroscopy

磁共振波谱

DOI：
发表时间：
2006
期刊：
Clinical Neuroscience 24・4
影响因子：
0
作者：
Sumitani S;Harada M;et al.;Hattori Y;Sumitani S;Ando H;Maeda N;原田雅史;Morita N;原田雅史;原田雅史;原田雅史
通讯作者：
原田雅史

脳神経外科学大系第2巻検査・診断法MRS

神经外科第 2 卷测试和诊断方法 MRS