Establishment of non-invasive tool for evaluating brain neural activity in chronic pain patients using magnetic resonance spectroscopy.

建立使用磁共振波谱评估慢性疼痛患者脑神经活动的非侵入性工具。

• 批准号: 20591826
• 负责人: FUKUI Sei
• 金额: $ 2.83万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591826/
• 关键词: 疼痛管理学; MR Spectroscopy; 前帯状回; 前頭前野; NAA; GABA; Glutamate; 慢性疼痛; 局所脳神経機能; 前帶状回; 疼痛管理学; MR Spectroscopy; 前帯状回; 前頭前野; NAA; GABA; Glutamate; 慢性疼痛; 局所脳神経機能; 前帶状回

In patients with chronic pain and CRPS, in the anterior cingulate gyrus, compared to healthy volunteers, the average left NAA concentration was significantly decreased.In chronic neuropathic patients and CRPS patients, compared with less anxious patients, NAA concentrations in the anterior cingulate gyrus was significantly decreased in the patients with strong anxiety accompanying chronic pain.^1H-MRS was evaluated for regional brain function, and could be considered a useful way to evaluate changes in pain processing mechanisms in the brain.As a pilot study,in healthy subjects, using a 3T MRI system, glutamate concentration and GABA concentration were measured in anterior cingulate gyrus.In the anterior cingulate gyrus in patients with chronic pain, excitatory neurons in the brain, the concentration of the neurotransmitter glutamate, the inhibitory neurons, the concentration of the neurotransmitter GABA, ready to be measured now. Using ^1H-MRS, evaluation of neural activity of excitatory neurons and the inhibitory neurons in the brain become possible.

与健康的志愿者相比，在慢性疼痛和CRP的患者中，在前扣带回后回去，平均左NAA浓度显着降低。与焦虑的患者相比，慢性神经病患者和CRPS患者与焦虑症患者相比，NAA的浓度较低，前扣带回的伴有型较强的焦虑症的患者在脑部伴随着脑部的疼痛均显着降低。 to evaluate changes in pain processing mechanisms in the brain.As a pilot study,in healthy subjects, using a 3T MRI system, glutamate concentration and GABA concentration were measured in anterior cingulate gyrus.In the anterior cingulate gyrus in patients with chronic pain, excitatory neurons in the brain, the concentration of the neurotransmitter glutamate, the inhibitory neurons, the concentration of the神经递质GABA，现在可以测量。使用 ^1H-MRS，可以评估兴奋性神经元和大脑抑制性神经元的神经活性。