Studies on the effect of low intensity ultrasound to accelerate bone formation around implants

低强度超声加速种植体周围骨形成效果的研究

• 批准号: 15592058
• 负责人: HAMANO Tohru
• 金额: $ 2.18万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15592058/
• 关键词: implant; bone formation; ultrasound; osseointegration

We investigated if low-intensity pulsed ultrasound (LIPUS) accelerates bone formation around implants. Rats were given titanium screw (Micro PLUS, Leibinger, Germany) implanted in their bilateral tibiae. LIPUS was daily administrated to right tibia, and not to left tibia as an internal control.Experiment 1 : Morphological study with a micro focus computerized tomography (micro CT)Six rats were divided into 2 groups: Three rats received LIPUS treatment for 4 days, and the others for 7 days. Then tibiae were harvested and were scanned using a micro CT (ELE SCAN, Nittetsu elex ). For morphological observation of bone formation around implants, 3D-images were constructed using image analyzing soft. Due to the halation of implants, the micro CT images were not obvious. In results, no apparent difference was observed between bilateral tibiae in either 4-days group or 7-days group.Experiment 2 : Mechanical evaluation for fixation of implant in tibiaeTo evaluate the mechanical stability of implant, removal torque of screw in 6 rats were measured using a torque gauge (ATG6CN, TOHNICHI) after unilateral LIPUS application for 7 days. The removal torque of screw was smaller than the insert torque in each rat, and displayed no apparent differences between bilateral tibiae. It was considered the cortical bone of tibiae was destroyed so much that screw could not be fixed in bone.In this study, the effect of LIPUS to accelerate bone formation around implants was not shown. In further study, the other animal model for implant study was needed.

我们研究了低强度脉冲超声（Lipus）是否会加速植入物周围的骨形成。将大鼠的钛螺钉（Micro Plus，Leibinger，德国）植入双侧胫骨。 Lipus每天都被胫骨右胫骨管理，而不是将胫骨作为内部控制。经验1：具有微聚焦计算机断层扫描（Micro CT）的形态学研究（Micro CT）将六只大鼠分为2组：三只大鼠接受了4天的Lipus治疗，其他人则为7天。然后收集胫骨，并使用微CT（Elee Scan，Nittetsu Elex）扫描。为了对植入物周围的骨形成的形态学观察，使用图像分析软构建了3D图像。由于植入物的一半，微型CT图像并不明显。在结果中，在4天组或7天组中双侧胫骨之间均未观察到明显的差异。实验2：胫骨中植入物固定的机械评估评估植入物的机械稳定性，使用A扭矩表（atg6cn，tohnichichi，tohnichiichi fornichal lip）测量了植入物的机械稳定性，在6个大鼠中拧下螺钉在6个大鼠中的移除扭矩。螺钉的去除扭矩小于每只大鼠中插入扭矩，并且双侧胫骨之间没有明显的差异。它被认为是胫骨的皮质骨被破坏了，以至于无法固定在骨头中。在这项研究中，没有显示脂肪在植入物周围加速骨形成的作用。在进一步的研究中，需要其他用于植入物研究的动物模型。