Study about safety and efficacy of percutaneous radiofrequency ablation for lung tumor

经皮射频消融治疗肺部肿瘤的安全性和有效性研究

• 批准号: 15591294
• 负责人: MATSUOKA Toshiyuki
• 金额: $ 1.86万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591294/
• 关键词: radiofrequency ablation; lung ncoplasm; CT-guided puncture

As fundamental experiment, we performed RFA in normal lungs of a pig and observed histopathological findings in comparison with a CT image. As a result, three layer configurations which consisted of central coagulative necrosis, the surrounding exudates and the most outer circumferential blood stasis were observed. It was thought that the circular high density area observed in CT corresponded in the most outer circumferential blood stasis with inflammatory cell invasion and fibrosis. The cellular group that did not reach necrosis lay scattered in the most outer circumferential layer. That means that it was important to get a good therapeutic effect at a clinical treatment that target lesion should be included inside the circular high density area in CT.22 nodules (ten postoperative recurrences of primary lung cancer and 12 metastases from the other organ) of 17 case could be added during study period. So, out of 86 nodules we performed RFA on since June 2000 till now, we evaluated clin … More ical results in 40 nodules less than 3cm which were observed more than 6 months after RFA.Local control rate was 81.8% in 33 nodules which reached roll off although it was 28.6% in seven nodules which did not do roll off. A significant difference was recognized between both. As for major complications, it revealed pain and/or heat sensation in 57.2%, postoperative fever in 51.4% and pneumothorax in 30.4%. Serious complications were not experienced except two cases who were inserted a chest tube because of moderate pneumothorax.We reported these results at the 33rd meeting of society of Japanese angiography and IVR (Tokyo), the 45th meeting of Japan lung cancer society (Yokohama), RSNA2004 (Chicago), ECR2005 (Vienna). In addition, occurrence of intravascular microembolisms caused by heat during RFA procedure was evaluated. Mocroemboli were observed in three of 20 procedures in 17 cases by monitoring a carotid artery using ultrasound image. However, diffusion MRI showed no cerebral infarction in 20 cases containing containing 17 US cases. The result was reported in American Journal of Roentogenology. Less

作为基本实验，我们在猪的正常肺中进行了RFA，并观察到与CT图像相比的组织病理学发现。结果，观察到由中央凝血坏死组成的三层构型，周围的渗出液和最外面的圆周血液停滞。据认为，在CT中观察到的圆形高密度区域在最外部的圆周血液停滞中与炎症细胞浸润和纤维化相对应。未达到坏死的细胞组散布在最外侧的层中。这意味着在临床治疗中获得良好的治疗作用是在CT.22个结节中应包括靶病变的靶病变（在研究期间，可以添加17例17例的原发性肺癌的圆形高密度区域（十项后肺癌的10个后术后回报）。因此，自2000年6月以来，在86个结节中，我们进行了RFA，我们评估了临床……在RFA后6个月以上，在40个小于3厘米的结节中进行了更多的结果。在RFA后6个月以上，在33个结节中，该local的控制率为81.8％，尽管它在七个结节中达到了28.6％，但在没有滚动的七个结节中，这是28.6％。两者之间都认识到一个显着差异。至于主要并发症，它显示出57.2％的疼痛和/或热感，术后发烧为51.4％，气胸为30.4％。除了两个因现代气胸而被插入胸管的病例外，没有经历过严重的并发症。我们在日本血管造影学会和IVR协会和IVR协会（Tokyo）的第33届会议上报告了这些结果，日本肺癌协会（Yokohama），RSNA2004（芝加哥）（芝加哥），ECR2005（Vienna）的第45届会议（Yokohama）。另外，评估了在RFA手术过程中由热量引起的血管内微栓塞的发生。通过使用超声图像监测颈动脉，在20例手术中，在20个手术中的三个过程中观察到了摩托栓塞。然而，扩散MRI在包含17例美国病例的20例中没有显示脑梗塞。该结果在《美国roentogenologeny杂志》中报道。较少的

项目成果

Radiofrequency ablation in a porcine lung model : correlation between CT and bistopathology.

猪肺模型中的射频消融：CT 和双病理学之间的相关性。

• 发表时间: 2005
• 期刊: American Journal of Roentgenology 185(in printing)
• 作者: Yamamoto A.;Nakamura K.;Matsuoka T.et al.
• 通讯作者: Matsuoka T.et al.

肺癌に対するCTガイド下経皮的ラジオ波凝固療法

CT引导下经皮射频凝固治疗肺癌

• 发表时间: 2004
• 期刊: 臨床放射線 49・4
• 作者: 松岡 利幸;山本 晃;大山 嘉将;他
• 通讯作者: 他

Assessment of Cerebral Microembolism During Percutaneous Radiofrequency Ablation of Lung Tumors Using Diffusion-Weighted Imaging.

使用扩散加权成像评估经皮射频消融肺部肿瘤期间的脑微栓塞。

• 发表时间: 2004
• 期刊: American Journal of Roentgenology 183
• 作者: Yamamoto A.;Matsuoka T.;Toyoshima M.et al.
• 通讯作者: Toyoshima M.et al.

松岡利幸, 中村健治, 井上清俊, 他: "ラジオ波焼灼療法 肺癌のRFA"Radiology Frontier. 6・4. 281-284 (2003)

Toshiyuki Matsuoka、Kenji Nakamura、Kiyotoshi Inoue 等：“射频消融疗法：RFA 治疗肺癌”放射学前沿 6・4（2003 年）。

Usefulness of Computed Tomography for Evaluating Recurrence After Radiofrequency Ablation.

计算机断层扫描对于评估射频消融后复发的有用性。

• 发表时间: 2003
• 期刊: Japanese Journal of Lung Cancer. 43
• 作者: Oyama Y.;Matsuoka T.;Toyoshima M.;et al.
• 通讯作者: et al.