Molecular epidemiological study of preeclampsia for the purpose of constructing of a new preventive strategy

先兆子痫的分子流行病学研究，旨在构建新的预防策略

• 批准号: 15590508
• 负责人: HAMADA Hiromi
• 金额: $ 2.24万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590508/
• 关键词: preeclampsia; genetic epidermplogy; gene polymorphism; proteome analysis; Clusterin

The purpose of this study was to detect genetic factor of preeclampsia and to construct of a new preventive strategy.The genes associated with preeclampsia were researched using the analysis of gene polymorphism and proteome analysis. And, interaction between the environmental factor or life habit of the patients of preeclampsia and their genetic factor was analyzed.As a result of this study, new associated gene with preeclampsia was not found out by the analysis of gene polymorphism. Clusterin associated with preeclampsia could be first detected by the proteomic technique. (Proteomics. 2004) Also, new finding of association between third nerve palsy and serous retinal detachment in preeclampsia was obtained. (Hypertension in Pregnancy, 2006) However, the new association between the environmental factor or life habit of the patients and the preeclampsia related gene polymorphisms detected by our group (Journal of Medical Genetics,1997;Journal of Human Genetics,2000;Thrombosis and Haemostasis,2001;Journal of Human Genetics,2002) was not found in this study of a small sample size.

这项研究的目的是检测先兆子痫的遗传因素和新的预防策略的构建。使用基因多态性和蛋白质组分析的分析，研究了与先兆子痫相关的基因。并且，分析了先兆子痫患者的环境因素或生命习惯与其遗传因素之间的相互作用。由于这项研究的结果，通过对基因多态性的分析，找不到新的与先兆子痫相关的基因。与先兆子痫相关的簇可以首先通过蛋白质组学技术检测。 （蛋白质组学，2004年），还获得了先兆子痫的第三神经麻痹和浆液性视网膜脱离之间的关联的新发现。 （怀孕中的高血压，2006年），但是，我们小组检测到的患者环境因素或生命习惯与相关的基因多态性之间的新关联（《医学遗传学》，1997年；人类遗传学杂志，2000年；血栓形成和骨血栓形成和造血，2001年； 2001年；人类遗传学杂志，2002年）。

项目成果

Proteome analysis reveals elevated serum levels of clusterin in patients with preeclampsia

• DOI: 10.1002/pmic.200300565
• 发表时间: 2004-02
• 期刊: PROTEOMICS
• 影响因子: 3.4
• 作者: Hideki Watanabe;H. Hamada;N. Yamada;S. Sohda;K. Yamakawa‐Kobayashi;H. Yoshikawa;T. Arinami

Watanabe H, Hamada H, et al.: "Proteome analysis reveals elevated serum levels of clusterin in patients with preeclampsia"Proteomics. 4・2. 537-543 (2004)

Watanabe H、Hamada H 等人：“蛋白质组分析显示先兆子痫患者的血清浓度升高”蛋白质组学 4・2 (2004)。

Third nerve palsy and serous retinal detachment with preeclampsia

第三神经麻痹和浆液性视网膜脱离伴先兆子痫

• 发表时间: 2006
• 期刊: Hypertension in Pregnancy 25・1
• 作者: Hideki Watanabe