Standardization of Blood gas analysis

血气分析标准化

基本信息

批准号：
15590501
负责人：
FUKUNAGA Toshiharu
金额：
$ 1.92万
依托单位：
KANAZAWA MEDICAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590501/
关键词：
pH pCO_2 pO_2 certified reference materials tonometry

项目摘要

As a standard material for blood gas analysis, several test samples including human blood synthesized with tonometry, buffer-type control materials for quality control, and the certified reference materials were evaluated and compared. The requisite for such material is the stability and easiness to use. The certified reference materials were best for that purpose with respect to the response characteristics to the electrodes, inclusion of hemoglobin, easy handling, and the ability to trace the exact values.Using the certified reference materials, external quality assurance (EQA) for blood gas analyzers have been executed in 2003 and 2004 in collaboration with Japanese Association of Medical Technologists in Ishikawa, Toyama, and Fukui prefectures. The results of this survey were as follows :1. While pH and pCO_2 were correctly measured in most analyzers, there was a large variability of measured pO_2 especially in high pO_2 range. The origin of this large variability was considered du … More e to the decreased slope of the oxygen dissociation curve in the pressure range more than 100 mmHg. In EQA in 2004, therefore, the specified value of pO_2 was set to a smaller one and the variability of the measured pO_2 values decreased.2. A correction equation was made from the relationship between measured and specified values in each item. The distribution of measured values was greatly improved by applying this equation. I anticipate the same effect of this equation on the routine measurements.3. The difference of measured values was evaluated between 5 different types of analyzers. The number attended to the survey was more than 10 in each type of analyzer. The measured pH values were statistically significant between the types of analyzers, but the differences were small and were in the permissible range. The measured pCO_2 and pO_2 values were not statistically significant between the different types of analyzers.In conclusion, the certified reference materials were considered to be most useful for standardization of blood gas analysis. However, the materials show different characteristics from whole blood when applied to the equipment including a new type of sensor such as i-STAT. Further studies should be conducted in this respect. Less

作为血气分析的标准材料，对包括张力计合成的人体血液、用于质量控制的缓冲型对照材料以及有证标准物质在内的多种测试样品进行了评估和比较。这种材料的必要条件是稳定性和易于使用。就电极的响应特性、血红蛋白含量、易于操作以及追踪精确值的能力而言，经过认证的参考材料最适合此目的。使用经过认证的参考材料，可对血液进行外部质量保证 (EQA)。气体分析仪2003 年和 2004 年与日本医疗技术专家协会在石川县、富山县和福井县合作进行了这项调查，结果如下：1. 虽然大多数分析仪都能正确测量 pH 和 pCO_2，但存在较大偏差。测量的 pO_2 的变异性，特别是在高 pO_2 范围内，这种大变异性的根源被认为是由于压力范围内氧解离曲线的斜率下降超过。 100 mmHg，因此，在2004年的EQA中，pO_2的规定值被设置为较小的值，并且测量的pO_2值的变异性减小。2.根据测量值和规定值之间的关系，得出校正方程通过应用该方程，我预计在每个项目中测量值的分布都会得到相同的效果。3.评估了 5 种不同类型的分析仪之间的测量值差异。参与调查的人数较多每种类型的分析仪测量的 pH 值均极其显着，但不同类型的分析仪测量的 pCO_2 和 pO_2 值之间差异很小且在允许的范围内。总之，经过认证的标准物质被认为对血气分析标准化最有用，但是，当应用于包括 i-STAT 等新型传感器的设备时，这些材料表现出与全血不同的特性。对此还需进一步研究。少尊重。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Evaluation of Accuracy of Blood Gas and Electrolyte Analyzer, OMNI C

血气和电解质分析仪的准确性评估，OMNI C

DOI：
发表时间：
2004
期刊：
Sysmex Journal 26
影响因子：
0
作者：
T.Fukunaga;Yhigashi;et al.
通讯作者：
et al.

血液ガス測定の正確さのサーベイ例の報告

血气测量准确度调查报告

DOI：
发表时间：
2004
期刊：
臨床化学 33・Supp.2
影响因子：
0
作者：
谷渉;福永壽晴;桑克彦;福永壽晴
通讯作者：
福永壽晴

血液ガス分析値の標準化に関する研究-血液ガス測定用標準物質の有用性-

血气分析值标准化研究-血气测量标准物质的用处-

DOI：
发表时间：
2004
期刊：
日本臨床検査自動化学会会誌 29・4
影响因子：
0
作者：
福永壽晴;中村正人;東由佳;他
通讯作者：
他

Quality Assurance for the POCT(Point of Care) in the Blood Gas Analysis using the Certified Reference Materials.

使用经过认证的标准物质进行血气分析中 POCT（护理点）的质量保证。

DOI：
发表时间：
2005
期刊：
JJCLA 30(1)
影响因子：
0
作者：
Y.Higashi;T.Fukunaga;et al.
通讯作者：
et al.

Standardization of blood gas analysis -Usefulness of the certified reference materials-

血气分析的标准化 -标准物质的有用性-

DOI：
发表时间：
2004
期刊：
Proceeding of the 20^<th> international symposium on critical care and point of care testing
影响因子：
0
作者：
東由佳;福永壽晴;長口涼香;他;福永壽晴;T.Fukunaga
通讯作者：
T.Fukunaga