Synthesis of functionalized polymer particles using poly(vinyl ether)-based sequential macromonomers with controlled architecture

使用具有受控结构的基于聚（乙烯基醚）的序列大单体合成功能化聚合物颗粒

• 批准号: 15550184
• 负责人: MINODA Masahiko
• 金额: $ 2.37万
• 依托单位: Kyoto Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15550184/
• 关键词: sequential macromonomer; amphiphilic block copolymer; living cationic polymerization; vinyl ether; dispersion polymerization; emulsion polymerization; monodisperse polymer particles; functionalized particle surfaces; スチレン末端型マクロモノマー; 表面官能基; グルコース

Polymer particles having functional groups on their surfaces are attracting much interest in a variety of scientific field. In this study, monodisperse functionalized polymer particles were synthesized by employing poly(vinyl ether)-based macromonomers with various pendant functions. Functionalized vinyl ethers(VEs) (CH_2=CH-OR, R:-CH_2CH_2OCH_2CH_2OCH_3, glucose residue) were subjected to living cationic polymerization initiated by CH_3CH(Cl)OCH_2CH_2OCOC(CH_3)=CH_2/ZnI_2 to give homopolymer-type and sequential (block copolymer-type) amphiphilic macromonomers with well-defined structure. SEM and TEM observation revealed that monodispersed polymer particles in the size of submicron range were successfully prepared through dispersion copolymerization of the macromonomer and styrene(St) in ethanol/water or emulsion copolymerization of them. Effects of the macromonomer structures and polymerization conditions on the size and shape of the polymer particles were also investigated. The dried … More polymer particles were capable of forming stable aqueous dispersions, suggesting the poly VE chains are located on the particle surfaces and improve the dispersion stability. Moreover, the glucose residues on the surfaces of glucose-coated particles were quantitatively analyzed. The glucose-coated particles in stable dispersions were found to be precipitated upon the addition of the glucose-binding protein, Con A. The precipitation was due to the cross-linking between the glucose residues on the particle surfaces with Con A.This study also describes the synthesis of a novel amphiphilic macromonomer with controlled structure and a styrenic end group by living cationic polymerization of VEs, and the preparation of functionalized polymer particles by dispersion copolymerization. Living polymers obtained by living cationic polymerization of methoxyethoxyethyl VE were treated with H_2O/HCl to give the precursor polymer with an aldehyde end group. Poly(VE)-based styrenic macromonomer (St-PMEEVE) was then synthesized by reductive amination of the aldehyde-capped precursor with 4-vinyl benzyl amine in the presence of NaBH(OAc)_3. Dispersion copolymerization of St and St-PMEEVE was carried out in ethanol/water to afford spherical polymer particles in the size of submicron range. Less

在其表面上具有官能团的聚合物颗粒吸引了各种科学领域的兴趣。在这项研究中，通过使用具有各种吊坠功能的基于聚（乙烯基醚）的宏观工具来合成单分散官能化的聚合物颗粒。 Functionalized vinyl ethers(VEs) (CH_2=CH-OR, R:-CH_2CH_2OCH_2CH_2OCH_3, glucose residence) were subjected to living cationic polymerization initiated by CH_3CH(Cl)OCH_2CH_2OCOC(CH_3)=CH_2/ZnI_2 to give homopolymer-type and sequential (block copolymer-type)具有明确定义的结构的两亲性宏观主义者。 SEM和TEM观察结果表明，通过在乙醇/水或乳液共聚物中，通过分散分散共聚和苯乙烯（ST）的分散共聚，成功制备了亚微米范围内的单分散聚合物颗粒。还研究了宏观经理结构和聚合条件对聚合物颗粒大小和形状的影响。干燥的……更多的聚合物颗粒能够形成稳定的水性分散体，这表明聚链链位于颗粒表面上并改善色散稳定性。此外，定量分析了葡萄糖涂层颗粒表面上的葡萄糖残差。 The glucose-coated particles in stable dispersions were found to Becomes precious upon the addition of the glucose-binding protein, Con A. The precision was due to the cross-linking between the glucose residuals on the particle surfaces with Con A. This study also describes the synthesis of a novel amphiphilic macromonomer with controlled structure and a styrenic end group by living cationic polymerization of VEs, and the preparation of通过分散共聚的官能化聚合物颗粒。通过用H_2O/HCL处理方法氧甲氧亚基VE获得的活阳离子聚合物获得的生物聚合物，从而将前体聚合物与醛端组相结合。然后在NABH（OAC）_3的情况下与4-乙烯基苯甲酰胺的氨基化合成，从而合成了基于聚（VE）的苯乙烯型巨球（ST-PMEEVE）（ST-PMEEVE）。在乙醇/水中进行ST和ST-PMEEVE的分散共聚，以提供亚微米范围内的球形聚合物颗粒。较少的

项目成果

Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid

• DOI: 10.1016/s0142-9612(03)00050-4
• 发表时间: 2003-06-01
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Kawashita, M;Nakao, M;Nakamura, T
• 通讯作者: Nakamura, T

Bonelike apatite formation on ethylene-vinyl alcohol copolymer modified with silane coupling agent and calcium silicate solutions

• DOI: 10.1016/s0142-9612(02)00581-1
• 发表时间: 2003-05-01
• 期刊: BIOMATERIALS
• 影响因子: 14
• 作者: Oyane, A;Kawashita, M;Nakamura, T
• 通讯作者: Nakamura, T

Apatite-forming ability of alginate fibers treated with calcium hydroxide solution

氢氧化钙溶液处理海藻酸盐纤维的磷灰石形成能力

• 发表时间: 2004
• 期刊: J.Mater.Sci. : Mater.Medicine 15(9)
• 作者: Hirokazu Nakayama;Hirokazu Nakayama;Hirokazu Nakayama;T.Kokubo
• 通讯作者: T.Kokubo

Controlled synthesis of glycopolymers with various molecular architectures by TEMPO-mediated polymerization

通过 TEMPO 介导的聚合控制合成具有各种分子结构的糖聚合物

• 发表时间: 2003
• 期刊: Prepr.of East Asia Symposium on Functional Dyes and Advanced Materials (Osaka, Oct 6-8)
• 作者: Hirokazu Nakayama;Hirokazu Nakayama;Hirokazu Nakayama;T.Kokubo;A.Oyane;M.Kawashita;Hirokazu Nakayama;M.Minoda;Hirokazu Nakayama;M.Minoda
• 通讯作者: M.Minoda

A.Oyane, M.Kawashita, K.Nakanishi, I.Kokubo, M.Minoda, T.Miyamoto, T.Nakamura: "Bonelike apatite formation on ethylene-vinyl alcohol copolymer modified with silane coupling agent and calcium silicate solutions"Biomaterials. 24(10). 1729-1735 (2003)

A.Oyane、M.Kawashita、K.Nakanishi、I.Kokubo、M.Minoda、T.Miyamoto、T.Nakamura：“用硅烷偶联剂和硅酸钙溶液改性的乙烯-乙烯醇共聚物上的骨状磷灰石形成”生物材料。