Research into the effects of sport activity on platelet and endothelial function and on development of atherosclerosis in children.

研究体育活动对血小板和内皮功能以及儿童动脉粥样硬化发展的影响。

基本信息

批准号：
15500431
负责人：
HORIGOME Hitoshi
金额：
$ 2.37万
依托单位：
University of Tsukuba
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500431/
关键词：
sports medicine pediatrics adult disease atherosclerosis platelet function coagulofibrinolysis 動脈硬化症

项目摘要

Introduction : Adult disease, including atherosclerosis, has its origins in childhood. Endothelial and platelet functions are implicated in progression of atherosclerosis. Although weight control is important for prevention of adult disease, changes in endothelial and platelet function due to growth or to exercise have not been clarified. Moreover, effective diet and/or exercise intervention from childhood has not been established. We investigated platelet activity and coagulofibrinolytic proteins that enhance endothelial function in children, adults and patients with cyanotic congenital heart disease (CCHD). We also assessed the effect of weight reduction on these markers.Materials and Method : 1.Plasma levels of soluble P-selectin, beta-thromboglobulin (beta-TG), platelet factor 4 (PF4), protein C and protein S in CCHD patients were measured. 2.Diurnal changes (9:00 am vs 4:00 pm) in plasminogen activator inhibitor-1 (PAI-1) activity and tissue-type plasminogen activator (t-PA) antig … More en levels in CCHD patients were evaluated. 3.Effects of weight reduction on platelet derived microparticles (PMP) released from activated platelets, PAI-1 activity and t-PA antigen were compared between 12-week calorie restricted diet with or without aerobic exercise in obese adults.Results : 1.Plasma levels of P-selectin, beta-TG,PF4 were significantly high, and those of free protein S antigen and protein C activity were significantly low in CCHD patients compared with acyanotic patients. P-selectin and beta-TG correlated positively, and protein S and protein C correlated negatively with hematocrit. 2.Morning increase of PAI-1 activity and t-PA antigen levels was observed in CCHD patients. Plasma levels of t-PA antigen at 9 am and 4 pm were higher in CCHD patients than those in acyanotic patients, and correlated positively with the levels of erythrocytosis. 3.PMP,PAI-1 activity and t-PA antigen values were elevated in obese adults in comparison with non-obese adults, and these three parameters correlated with body mass index (BMI). The intervention significantly reduced PMP,PAI-1 and t-PA antigen levels. There was a significant correlation between percentages of change in PMP values and those in BMI, fat tissue mass.Conclusion : Weight reduction appears to be essential for prevention of adult disease, through improvement of endothelial and platelet functions. There were platelet and coagulofibrinolytic abnormalities in CCHD patients who were exposed to chronic hypoxia. Strenuous exercise would induce transient tissue hypoxia. Establishment of appropriate diet and exercise therapies for age could contribute to prevention of adult disease from childhood. Less

简介：包括动脉粥样硬化在内的成人疾病起源于童年。内皮和血小板功能在动脉粥样硬化的进展中实现。尽管控制体重对于预防成人疾病很重要，但尚未阐明由于生长或运动而导致的内皮和血小板功能的变化。此外，尚未建立有效的饮食和/或运动干预。我们研究了血小板活性和凝血纤维蛋白蛋白，从而增强儿童，成人和氰基先天性心脏病（CCHD）患者的内皮功能。我们还评估了体重减轻对这些标记的影响。材料和方法：1。测量CCHD患者中固体P-选择蛋白，β-TROMBOMBOBOBOBOLIN（β-TG），血小板因子4（PF4），蛋白C和蛋白质S的血压水平。 2.纤溶酶原激活剂抑制剂1（PAI-1）活性和组织型纤溶酶原激活剂（T-PA）抗原的二型变化（9:00 am vs 4:00 pm）抗血脂的变化。评估了CCHD患者中更多的EN水平。 3.比较从活化血小板，PAI-1活性和T-PA抗原释放的血小板衍生微粒（PMP）的体重减轻的影响，在12周的卡路里受限饮食之间进行肥胖成人中有或没有有氧运动的饮食饮食。1。1. P-SELECTIN，beta-tg，beta-tg，PF4的pf4量显着高，蛋白质的蛋白质显着较高。与伴有伴烷烃患者。 p-选择蛋白和β-TG与血细胞比容呈负相关，蛋白质和蛋白质C呈正相关。 2.在CCHD患者中观察到PAI-1活性和T-PA抗原水平的提高。 CCHD患者的T-PA抗原的血浆水平高于伴呈现的患者的血浆水平高，并且与红细胞增多症的水平正相关。 3.与非肥胖成年人相比，肥胖成年人的PMP，PAI-1活性和T-PA抗原值升高，这三个参数与体重指数（BMI）相关。干预措施显着降低了PMP，PAI-1和T-PA抗原水平。 PMP值的变化百分比与BMI的脂肪组织质量之间存在显着相关性。结论：减轻体重似乎是通过改善内皮和血小板功能来预防成人疾病至关重要的。暴露于慢性缺氧的CCHD患者中有血小板和凝血纤维蛋白水解异常。剧烈运动会诱发瞬时组织缺氧。建立适当的年龄饮食和运动疗法可能会导致从小就预防成人疾病。较少的