Analysis of cutaneous vasodilatation by the use of blood flow mapping

利用血流图分析皮肤血管舒张

基本信息

批准号：
12470012
负责人：
SUGENOYA Junichi
金额：
$ 10.69万
依托单位：
Aichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

1. Topographical distribution of sweat rate and cutaneous blood flow was analyzed to investigate the neural mechanism of cutaneous active vasodilatation.2. Cutaneous blood flow was recorded at 50 sites over the forearm skin areas of 10 x 5 mm using a non-contact type 4-channel probe by laser-Doppler flowmetry, and whether the transient vasodilatation responses occur was studied. The results indicated that the vasodilatation responses could be detected equally at any sites.3. Active sweat glands were identified on the back skin using an iodine-starch method, and the cutaneous blood flow was recorded at the sweat gland sites and at the non-gland sites between the sweat glands. The results indicated that transient vasodilatation responses occurred at the non-gland sites as well as at the sweat gland sites.4. Sweat distribution maps were constructed for the back skin area of 20 x 20cm using two techniques : one, iodine-starch method, and the other, the ventilated capsule method. These maps were contrasted with blood flow distribution maps that were constructed using a laser-Doppler scanning instrument (Moor, LDI). The results indicated that the areas where sweating was profuse and the areas where cutaneous blood flow was abundant did not coincide in most cases, and in some cases the areas where sweating was profuse tended to correspond to the areas where cutaneous blood flow was rather low.5. These results enhance the possibility that the vasodilator nerve system mediates the cutaneous active vasodilatation, although they do not diminish the possibility that sudomotor nerve system mediates it (via vasodilative peptides).6. The technical limitations, such as the resolution of flowmetry or the accuracy of sweat maps, have to be overcome. In addition, the regulatory mechanism for cutaneous blood flow should be hereafter investigated on the perspective that vasodilator nerve system may be really important.

1．分析出汗率和皮肤血流量的地形分布，探讨皮肤主动舒张血管的神经机制。2．通过激光多普勒血流计，使用非接触型4通道探头记录前臂10×5mm皮肤区域的50个部位的皮肤血流，并研究是否发生短暂的血管舒张反应。结果表明，血管舒张反应在任何部位均可同等检测到。3．使用碘淀粉法识别背部皮肤上的活跃汗腺，并记录汗腺部位和汗腺之间的非腺部位的皮肤血流量。结果表明，非汗腺部位和汗腺部位均出现短暂的血管舒张反应。 4．使用两种技术为 20 x 20 厘米的背部皮肤区域构建汗水分布图：一种是碘淀粉法，另一种是通风胶囊法。这些图与使用激光多普勒扫描仪（Moor，LDI）构建的血流分布图进行了对比。结果表明，大多数情况下，出汗多的区域和皮肤血流丰富的区域并不重合，并且在某些情况下，出汗多的区域往往与皮肤血流较低的区域相对应。 5.这些结果增强了血管舒张神经系统介导皮肤主动血管舒张的可能性，尽管它们并没有减少催汗神经系统介导皮肤主动血管舒张的可能性（通过血管舒张肽）。6．必须克服技术限制，例如流量测定的分辨率或汗液图的准确性。此外，从血管舒张神经系统可能确实重要的角度来看，今后还应该研究皮肤血流的调节机制。