Development of Continuous Preparation Process of Functional Microspheres Using Continuous Reactor with Vibrating

振动连续反应器连续制备功能微球工艺的开发

• 批准号: 11555202
• 负责人: KAWANO Yoshinobu
• 金额: $ 7.23万
• 依托单位: MIYAZAKI UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11555202/
• 关键词: Microcapsules; Boidegradable Polymer; Agricultural Chemicals; Solvent Evaporation Method; Controlled Release; Particle diameter; Continuous preparation apparatus; 微粒子; 連続調整装置; 農薬マイクロカプセル; 農薬の地中内動態; (農薬)スミチオン; スチレンポリマー; 連続乳化装置; 内包特性; 粒子形状

Biodegradable microcapsules entrapping activated carbon impregnated with fenitrothion (MEP) which was used as a pesticide were prepared by the solvent evaporation method in a (solid/oil/water) complex emulsion system Biodegradable poly-caprolactone (PCL) was used as a wall material. Effects of preparation conditions (polymer concentration, surfactant concentration, hold-up of dispersed phase, MEP concentration, emulsion stabilizer, agitation speed) on the capsule morphology, entrapment efficiency and release profile of MEP were investigated. The microcapsules were able to be successfully prepared under the condition in which there were relatively large quantities of PCL and activated carbon for MEP. The release profile of MEP would be able to control by the preparation condition of the microcapsules. The effectiveness test for the plant of the microencapsulated pesticide (MEP), such as sustained-release performance and crop injury, was carried out. It was confirmed that the encapsulation was effective for the pesticide.Furthermore, the continuous apparatus with vibration mixing plates for the production of microcapsules and microspheres was developed. The continuous preparation of microcapsules were carried out by the in-situ polymerization in the O/W emulsion system of styrene and divinylbenzene at various conditions. Then, the operation method by this process was examined and the operating condition was clarified. Furthermore, the continuous preparation procedure of the pesticide microcapsules which made biodegradable polymer was developed.

在（固体/油/水）复杂乳液系统可生物降解的可降解多聚二氨基二氨基酯（PCL）中，用溶剂蒸发方法浸入用作农药的可生物降解的微胶囊被用作农药的活性碳被用作壁材料。研究了制备条件（聚合物浓度，表面活性剂浓度，分散相，MEP浓度，乳液稳定剂，搅拌速度）对胶囊形态，夹层效率和MEP的释放曲线的影响。在相对较大的PCL和MEP活化的碳的条件下，微胶囊能够成功制备。 MEP的释放曲线将能够通过微胶囊的制备条件来控制。进行了微囊化农药（MEP）的有效性测试，例如持续释放性能和作物损伤。据证实，封装对农药有效。FURTHERMORE，开发了带有振动混合板的连续装置，用于生产微胶囊和微球。在各种条件下，通过苯乙烯和divinylbenzen的O/W乳液系统中的原位聚合进行微胶囊的连续制备。然后，检查了该过程的操作方法，并阐明了操作条件。此外，开发了可生物降解聚合物的农药微胶囊的连续制备程序。

项目成果

Y.Kawano,K.Shiomori,S.Kiyoyama,Y.Hatate: "Prepatration and Characteristics of Protein Entrapped Biodegaradative Microcapsules"Pros.of The 8th APCChE Congress. 3. 901-904 (1999)

Y.Kawano,K.Shiomori,S.Kiyoyama,Y.Hatate：“蛋白质包埋生物降解微胶囊的制备和特性”第八届 APCChE 大会的优点。

清山史朗、塩盛弘一郎、河野恵宣、深田啓輔、幡手泰雄: "振動型乳化器を用いたエマルションの連続調製"化学工学論文集. 26・1. 81-87 (2000)

Shiro Kiyoyama、Koichiro Shiomori、Yoshinobu Kono、Keisuke Fukada、Yasuo Hatate：“使用振动乳化器连续制备乳液”《化学工程学报》26・1（2000）。

Y.Kawano, K.Shiomori, S.Kiyoyama, Y.Hatate: "Characteristics of Biodegradable Microcapsules by Solvent Evaporation in (W/0/W) Emulsion System"Journal of Chemical Engineering of Japan. 34. 1182-1186 (2001)

Y.Kawano、K.Shiomori、S.Kiyoyama、Y.Hatate：“(W/0/W)乳液体系中溶剂蒸发的可生物降解微胶囊的特性”日本化学工程学报。

吉田昌弘, エテイク・マルドリ アテイ, 上村芳二, 畑中千秋, 河野恵宣, 幡手泰雄: "微生物の固定化単体としてのシングルコア型機能性マイクロカプセルの開発"ケミカルエンジニアリング. 46. 858-868 (2001)

Masahiro Yoshida、Atei Eteik Maldori、Yoshiji Uemura、Chiaki Hatanaka、Yoshinobu Kono、Yasuo Hatate：“用于固定微生物的单核功能微胶囊的开发”化学工程 46. 858-868 (2001)。

塩盛弘一郎,清山史郎,河野恵宣,幡手泰雄: "W/O/Wエマルションの液中乾燥法によるポリ乳酸マイクロカプセルへのタンパク質の内包制御"化学工学論文集. 26. 50-55 (2000)

Koichiro Shiomori、Shiro Kiyoyama、Yoshinobu Kono、Yasuo Hatate：“通过 W/O/W 乳液的浸没干燥控制聚乳酸微胶囊中的蛋白质封装”《化学工程杂志》26. 50-55 (2000)。