Caveolin-1: separating its signaling activites from its caveolae organelle forming abilities

Caveolin-1：将其信号活动与其细胞器形成能力分开

• 批准号: 401850-2011
• 负责人: Bernatchez, Pascal
• 金额: $ 2.19万
• 依托单位: University of British Columbia
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2011
• 资助国家: 加拿大
• 起止时间: 2011-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=487863
• 关键词: Caveolin; separating; its; signaling; activites

Caveolae (Latin for 'small caves') are flask-shaped membrane invaginations found in most mammalian cells. Caveolin-1, the main coat protein of caveolae, is the dominant protein for the formation of caveolae; mice lacking the Caveolin-1 gene also lack caveolae in every non-muscle cells, providing direct evidence that Caveolin-1 is directly responsible for caveolae assembly. Study of caveolae show that they contain many signalling molecules, and it is now well accepted that caveolae formation is one of the most established approach to segregate and organize signalling complexes in a tri-dimensional manner. The importance of caveolae research is such that one of the pioneer of caveolae research, Dr. Michael Lisanti, is now the 13th most cited scientist of all time.

Caveolae（拉丁语，意为“小洞穴”）是大多数哺乳动物细胞中发现的烧瓶状膜内陷。 Caveolin-1是小凹的主要外壳蛋白，是小凹形成的主导蛋白；缺乏Caveolin-1基因的小鼠在每个非肌肉细胞中也缺乏小凹，这提供了Caveolin-1直接负责小凹组装的直接证据。对小窝的研究表明，它们含有许多信号分子，现在人们普遍认为，小窝的形成是以三维方式分离和组织信号复合物的最成熟的方法之一。小窝研究的重要性是如此之大，以至于小窝研究的先驱之一 Michael Lisanti 博士现在是有史以来被引用最多的科学家中排名第 13 的。