Clinical and Basic Research of Dementia with Lewy bodies

路易体痴呆的临床与基础研究

• 批准号: 14370293
• 负责人: MIURA Satashi
• 金额: $ 3.65万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370293/
• 关键词: dementia with Lewy bodies; Parkinson's disease with dementia; Alzheimer's disease; visual cognitive impairments; autonomic disturbances; denepezil chloride; Lewy body; α-synuclein; パーキンソン病; アルツハイマー型痴呆; アルファ・シヌクレイン; タウ; 神経原線織変化; 幻視; 脳画像

1) Clinical researches:We studied clinical findings in DLB patients, and disclosed the following points;・Various visual cognitive impairments including visual hallucination, visual illusion, metamorphopsia and Capras syndrome are frequently present.・Autonomic disturbances including constipatio, and urinary incontinenia are so frequently found as in PD patients.・MRI shows usually mild to moderate atrophy in the medial temporal region, and SPELT indicates frequent, although not specific, decrease of rCBF in the occipital lobes.2) Neuropathological researches:We studied many DLB brains neuropathologically, and got the following results.・DLB(18%) was the third most frequent dementing illness following AD(43%) and VD(23%) in our geriatric hospital.・Lewy pathology was divided into 4 stages, and DLB cases with AD pathology had the 3^<rd> and 4^<th> stages. In addition, Lewy pathology was indicated to advance from the amygdala through the limbic cortex to the neocortex.・In the hippocampus, Lewy bodies occur first in the CA3-4, while NFTs in the CAI.・Recent immunostaining reconfirmed our previous findings showing a close relationship between Lewy bodies and nerve cell loss, and disclosed marked RNA oxidation and occurrence of cytokines and metric oxide synthase in the DLB brain.・TH-positive neurons are apt to degenerate in the cerebral cortex and hippocampus of the DLB brain.Recent immunohistochemistry of Lewy pathology and Alzheimer pathology diffwrentiates DLB from AD.

1）临床研究：我们研究了DLB患者中的临床发现，并披露了以下几点； ・各种视觉认知障碍，包括视觉幻觉，视觉幻觉，变质，变质和CAPRAS综合征。・自主疾病。包括4次的自主疾病，包括便秘和尿中的暂时性，在PD患者中经常发现，并在PD患者中表现出MRIRS MR MR。拼写经常表明枕叶中RCBF的降低频率。2）神经病理学研究：我们从许多DLB大脑神经病理学上进行了许多DLB大脑的研究，并得到以下结果。・ dlb（18％）是第三个经常性痴呆的疾病（AD AD（43％）和VD（43％）和VD（43％）和geriiciatiic divey。具有AD病理的DLB病例具有3^<rd>和4^<th>阶段。此外，表明路易病理学可以从杏仁核通过边缘皮层从杏仁核发展到新皮层。 DLB脑中的公制氧化物合酶。th阳性神经元易于在DLB脑的脑皮质和海马中退化。Lewy病理学的免疫组织化学和阿尔茨海默病理学病理学的病理学差异。

项目成果

レビー小体型痴呆と神経原線維変化型痴呆

路易体痴呆和神经原纤维缠结痴呆

• 发表时间: 2004
• 期刊: 老年医学 42
• 作者: 小阪憲司

小阪憲司: "レビー小体型痴呆の治療痴呆患者の治療ガイドライン(中村重信編)"ワールドプランニング. 95-99 (2003)

Kenji Kosaka：“路易体痴呆症患者的治疗指南（由 Shigenobu Nakamura 编辑）” 世界规划 95-99（2003 年）。

丸井和美: "レビー小体型痴呆患者にみられる精神症状の特徴"臨床精神医学. 36・6. 657-664 (2002)

丸井和美：“路易体痴呆患者的精神症状特征”《临床精神病学》36・6（2002）。

Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson's disease with dementia

• DOI: 10.1016/s0022-510x(03)00220-x
• 发表时间: 2003-12-15
• 期刊: JOURNAL OF THE NEUROLOGICAL SCIENCES
• 影响因子: 4.4
• 作者: Horimoto, Y;Matsumoto, M;Kosaka, K
• 通讯作者: Kosaka, K

Serum ghrelin concentrations in patients receiving olanzapine or rispedorine.

接受奥氮平或利培多林治疗的患者的血清生长素释放肽浓度。

• 发表时间: 2004
• 期刊: Psychophanmacology 172
• 作者: Shikano N.;Kawai K.;et al.;Togo T
• 通讯作者: Togo T