Highly-sensitive vibrational spectrascopy with spatial resolution beyond diffraction limit

空间分辨率超出衍射极限的高灵敏度振动光谱

• 批准号: 14340189
• 负责人: FUTAMATA Masayuki
• 金额: $ 8万
• 依托单位: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14340189/
• 关键词: Surface Plasmon; Near-field spectroscopy; Single Molecule Detection; Slab Optical Waveguide; Surface enhanced Raman scattering; フェムト秒時間分解分光; 準弾性光散乱法; 過渡反射格子; 誘導ラマン散乱

The following results were obtained.1)Single molecule detection using SERS : a)Critical importance of the junction was proved using correlation between SERS and elastic scattering spectra from the same Ag nanoparticles, 2)adenine which has no electronic absorption in visible wavelength provides enormous enhancement similar to dye, 3)emission spectra originated from inelastic scattering of surface electron by adsorbed species was found for the first time.2)ATR-SNOM-Raman spectroscopy : a)interference or multiple scattering of LSP field do no essentially affect the near-field Raman imaging.3)FT-IR based ATR near-field spectrometer was built to demonstrate tip-enhanced IR absorption.4)Slab optical waveguide spectroscopy : ITO based waveguide was fabricated and applied to elucidate potential dependence of biomolecules with significantly high sensitivity.

获得以下结果。 1）使用SERS进行单分子检测：a）使用SERS和来自相同Ag纳米颗粒的弹性散射光谱之间的相关性证明了结的关键重要性，2）在可见波长中没有电子吸收的腺嘌呤提供了巨大的类似于染料的增强，3）首次发现了源自吸附物质表面电子非弹性散射的发射光谱。2）ATR-SNOM-拉曼光谱：a）LSP场的干涉或多散射基本上不会影响近场拉曼成像。3) 构建基于 FT-IR 的 ATR 近场光谱仪来演示尖端增强的红外吸收。4) 平板光波导光谱：制造并应用基于 ITO 的波导来阐明电位依赖性具有极高灵敏度的生物分子。

项目成果

Z.Qi, N.Matsuda, A.Takatsu, K.Kato: "A Kinetic Study of Cytochrome c Adsorption to Hydrophilic Glass by Broad-Band, Time-resolved Optical Waveguide Spectroscopy"Journal of Physical Chemistry B. 107. 6873-6875 (2003)

Z.Qi、N.Matsuda、A.Takatsu、K.Kato：“通过宽带时间分辨光波导光谱对细胞色素 c 吸附到亲水性玻璃的动力学研究”物理化学杂志 B. 107. 6873-6875

H.Yui, T.Nakajima, K.Hirao, T.Sawada: "Enhancement of the Stimulated Raman Scattering of Benzene-Toluene Mixtures under Strong Excitation Condition in the Liquid Phase"Journal of Physical Chemistry A. 107. 968-973 (2003)

H.Yui、T.Nakajima、K.Hirao、T.Sawada：“液相中强激发条件下苯-甲苯混合物的受激拉曼散射的增强”物理化学杂志 A. 107. 968-973 (2003)

M.Takahashi, H.Yui, Y.Ikezoe, T.Sawada: "Anomalous Change in Interfacial Tension Induced by Collapses of AOT Microemulsions at Heptane/Water Interface"Chemical Physics Letters. (受理済み、印刷中). (2004)

M.Takahashi、H.Yui、Y.Ikezoe、T.Sawada：“AOT 微乳液在庚烷/水界面塌陷引起的界面张力异常变化”《化学物理快报》（已接受，出版中）。

N.Matsuda, Jose H.Santos, A.Takatsu, K.Kato: "Spectroelectrochemical Studies on Surface Immobilized Cytochrome c on ITO electrode by Slab Optical Waveguide Spectroscopy"Thin Solid Films. 438-439. 403-406 (2003)

N.Matsuda、Jose H.Santos、A.Takatsu、K.Kato：“通过平板光波导光谱法对 ITO 电极上表面固定化细胞色素 c 进行光谱电化学研究”固体薄膜。

Y.Maruyama, M.Ishikawa, M.Futamata: "Thermal activation of Blinking in SERS"Journal of Physical Chemistry B.. 108. 673-678 (2004)

Y.Maruyama、M.Ishikawa、M.Futamata：“SERS 中闪烁的热激活”物理化学杂志 B.. 108. 673-678 (2004)