Construction of non-linear chemical information transaction system using allosteric interaction

利用变构相互作用构建非线性化学信息交易系统

• 批准号: 11450349
• 负责人: SHINKAI Seiji
• 金额: $ 6.98万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11450349/
• 关键词: Allosterism; Supramolecular Chemistry; Non-Linear; Molecular information; Molecular Recognition; アリステリズム; 情報伝達; ポルフィリン; ダブルデッカー型錯体; アロステリズム; シグナル増幅; 糖質; ボロン酸

The positive homotropic allosterism appears in important information transduction processes where chemical and physical signals are efficiently amplified. The phenomena are ubiquitously seen in nature but the general methodology to design such allosteric systems is not yet established in an artificial system. This article reviews such artificial receptors that can bind guest ions and molecules in a positive allosteric manner and discusses what kinds of factors are indispensable as scaffolds to design this novel class of allosteric systems and what are the common factors to realize the cooperativity. It has been shown that the scaffolds are mostly dynamic and are skillfully combined with the molecular recognition systems so that the subsequent guest binding can occur more favorably than the first guest binding. In addition, it has been suggested that the positive homotropic allosterism can be utilized as a new strategy to attain high guest selectivity and guest affinity which cannot be attained by conventional 1 : 1-type guest binding.

同型变构阳性在重要的信息转导过程中出现，在这些信息转导过程中，化学和物理信号有效放大。这种现象在自然界中无处不在，但是设计这种变构系统的一般方法尚未在人工系统中建立。本文回顾了可以以积极的变构方式绑定客人离子和分子的这种人造受体，并讨论了哪些因素是必不可少的，因为脚手架可以设计这种新颖的变构系统，以及实现合作性的常见因素。已经表明，脚手架大多是动态的，并且与分子识别系统巧妙地结合在一起，因此随后的宾客结合可以比第一个来宾结合更有利。此外，已经提出，可以将积极的同型变构主义用作新的策略，以达到高宾客的选择性和来宾亲和力，而传统的1：1型客体绑定无法实现。

项目成果

Y.Kubo, M.Ikeda, A.Sugasaki, M.Takeuchi, S.Shinkai: "Porphyrin Tetramer for Positive Homotropic Allosteric Recognition System : Efficient Binding Information Transduction through Butadiynyl Axis Rotation"Tetrahedron Lett.. 42. 7435-7435 (2001)

Y.Kubo、M.Ikeda、A.Sugasaki、M.Takeuchi、S.Shinkai：“用于正同向变构识别系统的卟啉四聚体：通过丁二炔基轴旋转进行有效的结合信息转导”Tetrahedron Lett.. 42. 7435-7435 (2001)

M.Takeuchi, M.Ikeda, A.Sugasaki, S.Shinkai: "Molecular Design of Artificial Molecular and Ion Recognition System with Allosteric Guest Responses"Acc.Chem.Res.. 34. 865 (2001)

M.Takeuchi、M.Ikeda、A.Sugasaki、S.Shinkai：“具有变构客体响应的人工分子和离子识别系统的分子设计”Acc.Chem.Res.. 34. 865 (2001)

M.Ikeda, S.Shinkai, A.Osuka: "Meso-meso-linked Porphyrin Dimer as a novel Scaffold for the Selective Binding of Oliaosaccharides"Chem. Commun.. 1047-1047 (2000)

M.Ikeda、S.Shinkai、A.Osuka：“内消旋-内消旋连接的卟啉二聚体作为选择性结合寡糖的新型支架”Chem。

木村 太郎: "Super-structures Can Be Constructed in Organogels from Combination of a Co-rnic-acid appended Bolaamphiphile with Chiral Diols"Tetrahedron Lett.. 40・36. 6631-6634 (1999)

木村太郎：“通过添加玉米酸的 Bolaamphiphile 与手性二醇的组合可以在有机凝胶中构建超结构”Tetrahedron Lett.. 40・36 (1999)。

水野 稔久: "Suger Sensing Using Chiral Salen-Co(II)Complex"Tetrahedron. 55・31. 9455-9468 (1999)

Toshihisa Mizuno：“使用手性 Salen-Co(II) 复合物进行糖传感”四面体 55・31 (1999)。