Interaction of secreting pathogenic factors in vibriosis.
弧菌病中分泌致病因子的相互作用。
基本信息
- 批准号:10470069
- 负责人:
- 金额:$ 6.21万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B).
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Bacteria of genus Vibrio are habitant of natural aquatic environment and include some pathogenic species which secret various pathogenic factors. These factors usually cause symptoms by cooperating with or complementing to other factors. This research project was carried out to understand general mechanism of vibriosis by studying cooperative and complementary action of pathogenic factors of vibrios, such as hemolysin, protease, siderphore or enterotoxin of Vibrio vulnificus and V.mimicus.Hemolysisn and proteases were extensively studied in this research. Proteases of vibrios causing systemic infection, such as V.vulnificus, act directly as the toxic factor by stimulating vascular permeability. However proteases of enteropathogenic vibrios, such as V.mimicus, show indirect action ; influencing the colonization mechanism by modifying intestinal membrane, activation or inactivation of protein toxins by partial digestion of the peptide for nicking some special part.Although hemolytic action of V.mimicus hemolysin was not influenced by partial digestion with protease produced by the vibrio, enterotoxic activity of the hemolysin was lost by the proteolysis. V.vulnificus hemolysin was also nicked by partial digestion of the vibrio protease, and the influenc to the activity was different between the hemolysins of biotype 1 and 2. These results are useful information for understanding mechanism of vibrio infection.
Vibrio属的细菌是天然水生环境的居民,其中包括一些致病物种,这些病原体秘密各种致病因素。这些因素通常通过与其他因素合作或补充来引起症状。该研究项目的目的是通过研究颤音的病原因子的合作和互补作用来理解颤动的一般机制,例如血解剂,蛋白酶,蛋白酶,siderphore或vibrio vibrio vulnificus和v.mimicus的毒素。 。引起全身感染的颤音的蛋白酶,例如V.Vulnififus,直接通过刺激血管通透性作为毒性因子。然而,肠病颤音的蛋白酶,例如v.mimicus,显示出间接作用。通过修饰肠膜,通过肽的部分消化来影响蛋白质毒素的肠膜,激活或灭活蛋白质毒素来影响定殖机制。MIMIMIMICUSHEMOLYSIN的溶血性作用并未受到纤维蛋白酶的蛋白酶的影响,蛋白质的溶血作用并未受到纤维,肠毒性毒素的影响,但并未受到纤维蛋白的影响。蛋白水解失去了血溶素。 V.Vulnificus Hemolysin也通过部分消化的纤维蛋白酶进行了划痕,并且在生物型1和2的生物型之间的影响不同。这些结果是了解弧菌感染机制的有用信息。
项目成果
期刊论文数量(42)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Bi, K., et al.: "Analysis of Vibrio mimicus clinical strains by arbitrarily primed polymerase chain reaction"Microbiol. Immunol.. 44. 149-153 (2000)
Bi, K. 等人:“通过任意引发的聚合酶链式反应分析拟态弧菌临床菌株”Microbiol。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Miyoshi, S. et al.: "The hemagglutinating action of Vibrio vulnificus metalloprotease"Microbiol. Immunol.. 43. 79-82 (1999)
Miyoshi, S. 等人:“创伤弧菌金属蛋白酶的血凝作用”微生物学。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Shi, L., Miyoshi, S., Shinoda S.et al.: "Presence of hemolysin genes (vmh, tdh and hlx) in isolates of Vibrio mimicus determined by polymerase chain reaction."J.Health Sci.. 46. 63-65 (2000)
Shi, L., Miyoshi, S., Shinoda S.等人:“通过聚合酶链式反应测定拟态弧菌分离株中溶血素基因(vmh、tdh 和 hlx)的存在。”J. Health Sci.. 46. 63
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Miyoshi,S.: "The hemagglutinating action of Vibrio vulnificus metalloprotease." Microbiology and Immunology. 43. 79-82 (1999)
Miyoshi,S.:“创伤弧菌金属蛋白酶的血凝作用。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Shinoda,S.,Miyoshi,S.: "Enteropathogenic factors produced by vibrios other cholera toxin."J.Natural Toxins.. 9. 231-249 (2000)
Shinoda,S.,Miyoshi,S.:“弧菌和其他霍乱毒素产生的肠道致病因子。”J.Natural Toxins.. 9. 231-249 (2000)
- DOI:
- 发表时间:
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- 影响因子:0
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SHINODA Sumio其他文献
SHINODA Sumio的其他文献
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{{ truncateString('SHINODA Sumio', 18)}}的其他基金
Ecological and molecular-epidemiological studies of Vibrio cholerae related bacteria in Indian Subcontinent
印度次大陆霍乱弧菌相关细菌的生态学和分子流行病学研究
- 批准号:
14406006 - 财政年份:2002
- 资助金额:
$ 6.21万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Studies of development of method for detection of aquatic pathogenic bacteria in viable but non-culturable stage and their ecology.
水生非可培养阶段病原菌检测方法及其生态学研究。
- 批准号:
10557236 - 财政年份:1998
- 资助金额:
$ 6.21万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
MECHANISM OF ACTION OF PORE FORMING TOXINS
成孔毒素的作用机制
- 批准号:
06454206 - 财政年份:1994
- 资助金额:
$ 6.21万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
DEVELOPMENT OF RAPID IDENTIFICATION METHOD OF PATHOGENIC VIBRIOS
致病性弧菌快速鉴定方法的研制
- 批准号:
05557106 - 财政年份:1993
- 资助金额:
$ 6.21万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
STUDIES ON PATHOGENIC FACTORS OF NON-HALOPHILIC PATHOGENIC VIBRIOS
非嗜盐致病弧菌致病因素的研究
- 批准号:
03670215 - 财政年份:1991
- 资助金额:
$ 6.21万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
One-step Synthesis of Acetic Acid from Methanol Alone Using Dual Functional Complex Catalysis
双功能络合物催化仅由甲醇一步合成乙酸
- 批准号:
02805101 - 财政年份:1990
- 资助金额:
$ 6.21万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Molecular Genetic Analysis and Mechanism of Action of Bacterial Cytolysins
细菌溶细胞素的分子遗传学分析及作用机制
- 批准号:
01304033 - 财政年份:1989
- 资助金额:
$ 6.21万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)
Structural Analysis of Flagella of Vibrio
弧菌鞭毛的结构分析
- 批准号:
01570238 - 财政年份:1989
- 资助金额:
$ 6.21万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
VIRURENCE FACTOR OF PATHOGENIC MARINE VIBRIOS
致病性海洋弧菌的毒力因子
- 批准号:
62570192 - 财政年份:1987
- 资助金额:
$ 6.21万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Membrane Separation and Pore Diffusion of Organic Molecules Adsorbed on Controlled-porous Acidic Ceramics
可控孔酸性陶瓷吸附有机分子的膜分离和孔扩散
- 批准号:
62550598 - 财政年份:1987
- 资助金额:
$ 6.21万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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