Genetic polymorphism and susceptibility of common cancer

常见癌症的基因多态性与易感性

• 批准号: 10470056
• 负责人: SUGIMURA Haruko
• 金额: $ 6.85万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10470056/
• 关键词: polymorphism; common cancer; stomach; lung; CPY; OGG; IL-1; gastritis; Cyp2E1; Cyp1A1; OGG1; 分子疫学; 肺癌; 胃癌; 症例対照研究; ニトロソアミン; hOGG1; 多型; 80H-グアニン

Rsal polymorphism of CYP2E1, Ser/Cys polymorphism of OGG1, Ile/Val polymorphism of CYP1A1, IL-1b polymorphism were evaluated in lung and gastric cancer case-controls and chronic gastritis with Helicobacter pylori infection. Val homozygotes, Cys homozygotes were related to the increased risk of squamous cell carcinoma of the lung after adjustment of smoking and age. CYP2E1 variant alleles played a protective role against gastric cancer when we adjusted meal consumption. IL-1b polymorphism is highly related with severity of chronic gastritis due to helicobacter pylori infection.A profile of chormosomal Instability of gastric cancer with high familial predisposition was different with that of sporadic gastric cancer.Effects of common environmental carcinogens like benzopyrene were investigated especially on the signaling molecules of pix and eph receptors.These observations together and segregation analysis of Japanese families of gastric cancel suggest existence of genetic predisposition in human common cancers and elucidation of these issues will facilitate a launch of so-called tailor made prevention and medicine.

CYP2E1，OGG1的Ser/CYS多态性的RSAL多态性，CYP1A1的ILE/VAL多态性，IL-1B多态性，IL-1B多态性在肺和胃癌病例对照和慢性胃炎中伴有幽门螺杆菌感染。 VAL纯合子，CYS纯合子与调整吸烟和年龄后肺部鳞状细胞癌的风险增加有关。当我们调整膳食消耗时，CYP2E1变体等位基因对胃癌发挥了保护作用。 IL-1B多态性与幽门螺杆菌感染引起的慢性胃炎的严重程度高度相关。胃癌与家族性高易感性的胃癌的结构性不稳定与零星胃癌的高度不同。与普通环境癌的效应。常见的环境致癌物（如苯并蛋白元素），尤其是苯佐皮烯，尤其是信号的受体，并具有分类为单位的分类。对日本胃取消家庭的隔离分析表明，人类普通癌中存在遗传易感性，并阐明这些问题将有助于推出所谓的裁缝预防和医学。

项目成果

Ying Wang: "Mutational analysis of multiple target genes in histologically heterogeneous gastric cancer with microsatellite instability." Japanese Journal of Cancer Research. 89. 1284-1291 (1998)

Ying Wang：“具有微卫星不稳定性的组织学异质性胃癌的多个靶基因的突变分析。”

Toshifumi Nakamura: "Hepatocellular Carcinoma in Type 1a Glycogen Storage Disease with Identification of a Glucose-6-Phosphatase Gene Mutation in One Family" Journal of Gastroenterology and Hepatology. (in press).

Toshifumi Nakamura：“1a 型糖原累积病中的肝细胞癌与一个家族中葡萄糖 6 磷酸酶基因突变的鉴定”《胃肠病学和肝脏病学杂志》。

Hanaoka T, Sugimura H. et al.: "hOGG1 exon7 polymorphism and gastric cancer in case-control studies of Japanese Brazilians and non-Japanese Brazilians"Cancer Letters. 170. 53-61 (2001)

Hanaoka T、Sugimura H. 等人：“日本巴西人和非日本巴西人的病例对照研究中的 hOGG1 外显子 7 多态性与胃癌”癌症快报。

Kanamori M, Sugimura H. et al.: "Segregation analysis of Gastric Cancer in Japanese Population"Int J Hum Genetics. 1(4). 263-270 (2001)

Kanamori M、Sugimura H. 等人：“日本人群胃癌的分离分析”Int J Hum Genetics。

Otsuki Y., Sugimura H. et al.: "Tumor metastasis suppressor nm23-H1 regulates Rac1 GTPase byinteraction with Tiam1"Proceedings National Academy of Science, USA.. 98(8). 4385-90

Otsuki Y.、Sugimura H. 等人：“肿瘤转移抑制因子 nm23-H1 通过与 Tiam1 相互作用调节 Rac1 GTPase”美国国家科学院院刊，98(8)。