Integrate Analysis of Blood Pressure Regulation System in CNS.
中枢神经系统血压调节系统的综合分析。
基本信息
- 批准号:10044301
- 负责人:
- 金额:$ 6.66万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B).
- 财政年份:1998
- 资助国家:日本
- 起止时间:1998 至 2000
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The carotid sinus reflex of the blood pressure is transmitted to the nucleus of the solitary tract (NTS) via baroreceptor nerve terminals in the aortic depressor nerve (ADN) which is located in the aortic arch. However, not only the detailed mechanisms on synapse transmission in the NTS neurons projected from ADN but also modulations of vasomotor reflex have not been clarified.In the present studies, the NTS neurons projected from ADN were identified 3-5 days after injection of Di-1 to the separated ADN.This ADN axon from nodose ganglion entered the brainstem to form the solitary tract (ST) and terminated the soma and dendrites of medial NTS neurons, which released glutamate. The identified medial NTS neurons were sensitive to kainate application by 2-fold relative to the non-projected neurons from ADN.ST evoked mono-synaptic glutamatergic responses were mediated by non-NMDA glutamate receptors in the medial NTS neurons. Furthermore, both capsaicin, a VR-1 (vanilloid) receptors agonist and a, b met ATP, a purinergic P2X3 receptors agonist, increased glutamate release 30-fold relative to the control value in dissociated medial NTS neurons, Which is suggested that vasodilation is manipulated capsaicin and ATP at brainstem level.This functional VR-1 and purinergic regulation might play an important role for any systemic therapies since NTS is exposed to an open blood brain barrier.
血压的颈动脉窦反射通过位于主动脉弓的主动脉降压神经(ADN)中的压力感受器神经末梢传递到孤束核(NTS)。然而,不仅ADN投射的NTS神经元突触传递的详细机制以及血管舒缩反射的调节尚未阐明。在本研究中,在注射Di-3-5天后,鉴定了从ADN投射的NTS神经元。 1到分离的ADN。来自结状神经节的ADN轴突进入脑干形成孤束(ST)并终止内侧NTS神经元的体细胞和树突,从而释放出谷氨酸。相对于来自 ADN 的非投射神经元,所鉴定的内侧 NTS 神经元对红藻氨酸应用敏感 2 倍。ST 诱发的单突触谷氨酸反应是由内侧 NTS 神经元中的非 NMDA 谷氨酸受体介导的。此外,辣椒素(一种 VR-1(香草素)受体激动剂)和 a, b met ATP(一种嘌呤能 P2X3 受体激动剂)在分离的内侧 NTS 神经元中,谷氨酸释放量相对于对照值增加了 30 倍,这表明血管舒张是在脑干水平操纵辣椒素和 ATP。这种功能性 VR-1 和嘌呤能调节可能对任何系统性发挥重要作用由于 NTS 暴露于开放的血脑屏障,因此需要进行治疗。
项目成果
期刊论文数量(21)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
kakazu,Akaike,Komiyama,Nabekura: "Regulation of Intracellular C1 by cotransporters in developing lateral superior olive neurons"Jouranl of Neuroscience. 19. 2843-2851 (1999)
kakazu、Akaike、Komiyama、Nabekura:“共转运蛋白在发育侧橄榄神经元中对细胞内 C1 的调节”神经科学杂志。
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- 影响因子:0
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Furukawa,Okada,Akaike,Hayashi,Nabekura: "Reduction of voltage dependent Mg^<2+> block of NMDA receptor mediated response after in vivo axonal inijury"Neuroscience. (印刷中).
Furukawa、Okada、Akaike、Hayashi、Nabekura:“体内轴突损伤后 NMDA 受体介导反应的依赖性电压 Mg^2+ 阻滞的减少”神经科学(出版中)。
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Noda,Nakanishi,Nabekura,Akaike: "AMPA-Kainate subtype of glutamate reeptor in rat cerebral microglia"Jouranl of Neuroscience. 20. 251-258 (2000)
Noda、Nakanishi、Nabekura、Akaike:“大鼠大脑小胶质细胞中谷氨酸受体的 AMPA-红藻氨酸亚型”神经科学杂志。
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- 影响因子:0
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Kishimoto, K., Koyama, S.& Akaike, N.: "Presynaptic modulation of synaptic γ-aminobutyric acid transmission by tandospirone in rat basolaterla amygdala"European J.Pharmacol.. 407. 257-265 (2000)
Kishimoto, K.、Koyama, S. 和 Akaike, N.:“大鼠 basolaterla 杏仁核中坦度螺酮对突触 γ-氨基丁酸传递的突触前调节”European J.Pharmacol.. 407. 257-265 (2000)
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- 影响因子:0
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- 通讯作者:
Kakazu, Y., Uchida, S., Nakagawa, T., Akaike, N.: "Reversibility and cation selectivity of the K+-Cl-cotransport in rat antralneurons."J.Neurophysiol.. 84. 281-288 (2000)
Kakazu, Y.、Uchida, S.、Nakakawa, T.、Akaike, N.:“大鼠窦神经元中 K -Cl 共转运的可逆性和阳离子选择性。”J.Neurophysiol.. 84. 281-288 (2000)
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- 影响因子:0
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AKAIKE Norio其他文献
AKAIKE Norio的其他文献
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{{ truncateString('AKAIKE Norio', 18)}}的其他基金
Analgesic effect of histamine at spinal synaptic level
组胺在脊髓突触水平的镇痛作用
- 批准号:
18613025 - 财政年份:2006
- 资助金额:
$ 6.66万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Study on the regulatory mechanisms of transmitter release from presynaptic nerve boutons in CNS
中枢神经系统突触前神经按钮释放递质的调节机制研究
- 批准号:
13307003 - 财政年份:2001
- 资助金额:
$ 6.66万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
FUNCTIONAL OF CaィイD12+ィエD1-Calmodulin sensitive a denylate cyclase in central neurons
CaD12+D1-钙调蛋白对中枢神经元否认环化酶敏感的功能
- 批准号:
10470009 - 财政年份:1998
- 资助金额:
$ 6.66万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Changes of excitatory and inhibitory amino acid responses in the relay neurons of lateral geniculate nucleus by optic nerve denervation
视神经去神经后外侧膝状核中继神经元兴奋性和抑制性氨基酸反应的变化
- 批准号:
07407002 - 财政年份:1995
- 资助金额:
$ 6.66万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Ca^<2+> and signal transduction in CNS neurones.
Ca ^ 2 和CNS神经元中的信号转导。
- 批准号:
04044029 - 财政年份:1992
- 资助金额:
$ 6.66万 - 项目类别:
Grant-in-Aid for international Scientific Research
THE CROSS TALK OF SIGNAL TRANSMISSION BETWEEN THE RECEPTOR AND THE CHANNEL
接收器与通道之间信号传输的串扰
- 批准号:
04304028 - 财政年份:1992
- 资助金额:
$ 6.66万 - 项目类别:
Grant-in-Aid for Co-operative Research (A)
METABOTROPIC GLUTAMATE RESPONSES IN PRE-AND POSTSYNAPTIC MEMBRANES -CROSSTALK IN THE SIGNAL TRANSDUCTION PATHWAYS-
突触前膜和突触后膜中的代谢性谷氨酸反应 - 信号转导途径中的串扰 -
- 批准号:
04404023 - 财政年份:1992
- 资助金额:
$ 6.66万 - 项目类别:
Grant-in-Aid for General Scientific Research (A)
Novel tetrodotoxin-sensitive Ca^<2+> current in mammalian neurons - function and distribution
哺乳动物神经元中新型河豚毒素敏感 Ca^<2> 电流 - 功能和分布
- 批准号:
02404022 - 财政年份:1990
- 资助金额:
$ 6.66万 - 项目类别:
Grant-in-Aid for General Scientific Research (A)
DEVELOPMENT OF NEW SYSTEM USED CAGED-COMPOUND BY WHICH THE PHYSIOLOGICAL FUNCTION OF CNS NEURONS CAN BE CLARIFIED.
开发使用笼状复合物的新系统,通过该系统可以阐明中枢神经系统神经元的生理功能。
- 批准号:
02557005 - 财政年份:1990
- 资助金额:
$ 6.66万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research (B)
Macro- and microscopic analysis of glycine-gated response in isolated CNS neurons.
分离的中枢神经系统神经元甘氨酸门控反应的宏观和微观分析。
- 批准号:
63480107 - 财政年份:1988
- 资助金额:
$ 6.66万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
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Understanding the functional role of kappa opioid receptor signaling in somatosensory neurons
了解卡帕阿片受体信号传导在体感神经元中的功能作用
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