Analysis of relationship between periodontal tissue para-inflammation induced neuroinflammation and phagocytic activity regulation by circadian cloclk system

牙周组织副炎症诱导的神经炎症与生物钟系统吞噬细胞活性调节关系分析

• 批准号: 24890161
• 负责人: OKADA Ryo
• 金额: $ 1.66万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890161/
• 关键词: 歯学; 歯周パラインフラメーション; 脳炎症; 食細胞; 体内時計; 歯学; 歯周パラインフラメーション; 脳炎症; 食細胞; 体内時計

To elucidate the mechanism of cognitive impairment by chronic inflammatory periodontal disease, also known as para-inflammation disease, we developed animal models of periodontal disease. After the application of P. gingivalis (PG) to periodontal tissues, proinflammatory cytokines were expressed at the periodontal tissue and cerebral cortex. and intraperitoneal administration of PG caused cognitive impairment.Microglia involved in cognitive impairment by producing proinflammatory cytokines under neuroinflammatory conditions. And recent studies showed that the abilities of microglia showed circadian rhythm. After the application of PG, proinflammatory cytokine mRNA expression levels in brain microglia and periodontal tissue macrophages showed circadian rhythm. These results suggested that circadian rhythm of proinflammatory cytokine gene expressions by periodontal tissue and brain phagocytes may affect periodontal tissue inflammation and cognitive impairment progression.

为了阐明慢性炎症性牙周疾病的认知障碍机制，也称为para炎症疾病，我们开发了牙周疾病的动物模型。将牙龈疟原虫（PG）应用于牙周组织后，在牙周组织和脑皮质上表达促炎性细胞因子。 PG的腹膜内给药会引起认知障碍。通过在神经炎症条件下产生促炎性细胞因子，涉及认知障碍的乳腺癌。最近的研究表明，小胶质细胞的能力显示昼夜节律。应用PG后，脑胶质细胞和牙周组织巨噬细胞中促炎性细胞因子mRNA表达水平水平显示出昼夜节律。这些结果表明，牙周组织和脑吞噬细胞促炎细胞因子基因表达的昼夜节律可能会影响牙周组织炎症和认知障碍的进展。