Preventive mechanisms of Epicatechin against cardiovascular event and examination of the action in the living body

表儿茶素对心血管事件的预防机制及其在生物体内的作用研究

• 批准号: 24890143
• 负责人: NAGAYASU SHINTARO
• 金额: $ 1.91万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890143/
• 关键词: エピカテキン; エピカテキン

It is suggested that minimal chronic inflammation caused by periodontal disease can become the arteriosclerotic exacerbation factor. On the other hand, it is reported by ingestion of the dark cocoa that a cardiovascular event incidence decreases, and a cardiovascular event suppressant effect of epicatechin(EC) which is the chief ingredient attracts attention. I paid my attention to Adipocyte-macrophage interaction and, in this study, examined the molecular mechanism of the cardiovascular event suppressant effect by the EC. As a result of having analyzed the change of inflammatory related molecules when I added LPS stimulation to the co-cultures, I was able to confirm the producing decrease of inflammatory related molecules by adding EC.These results suggested the possibility that a cardiovascular event incidence decreased by anti-inflammatory effect of the EC.

有人提出，由牙周疾病引起的最小慢性炎症可能成为动脉硬化加重因子。另一方面，通过摄入深色可可的摄入，心血管事件的发生率降低，以及epicatechin（EC）的心血管事件抑制作用（EC）的抑制作用，这是主要成分引起的关注。我关注脂肪细胞 - 巨噬细胞相互作用，在这项研究中，我检查了EC的心血管事件抑制效果的分子机制。由于分析了在共培养中添加LPS刺激时分析了炎症相关分子的变化，因此我能够通过添加EC来确认炎症相关分子的产生降低。这些结果表明，这些可能因EC抗炎作用而导致心血管事件降低的可能性。